Changes of serum PGⅠ/PGⅡ,sHLA-G and CCL20 in gastric precancerous lesions patients complicated with Hp infection and association with gastric cancer transformation
OBJECTIVE To explore the changes of serum pepsinogen Ⅰ/pepsinogen Ⅱ(PGⅠ/PG Ⅱ),soluble hu-man leukocyte antigen G(sHLA-G)and CC chemokine ligand 20(CCL20)in the gastric precancerous lesions pa-tients complicated with Helicobacter pylori(Hp)infection and analyze the association with gastric cancer trans-formation.METHODS Totally 118 patients with Hp infection who received gastroscopy in the First Affiliated Hos-pital of Xinxiang Medical University from Aug 2022 to Aug 2023 were enrolled in the study and were divided into the precancerous state group with 65 cases,the precancerous lesion group with 37 cases and the gastric cancer group with 16 cases according to the gastroscopic pathological diagnosis combined with serological indexes.The levels of serum PGⅠ/PGⅡ,sHLA-G and CCL20 were detected and compared among the three groups of patients,the relationship among the in-dexes and the association with gastric cancer transformation were analyzed.RESULTS The serum PGⅠ/PGⅡ level of the gastric cancer group was lower than that of the precancerous lesion group and the precancerous state group,while the levels of serum sHLA-G and CCL20 of the gastric cancer group were higher than those of the precancer-ous lesion group and the precancerous state group;the serum PGⅠ/PGⅡ level of the precancerous lesion group was lower than that of the precancerous state group,and the levels of serum sHLA-G and CCL20 of the precan-cerous lesion group were higher than those of the precancerous state group(P＜0.05).The serum PGⅠ/PGⅡ lev-el of the patients with Hp infection was negatively correlated with the serum sHLA-G and CCL20 levels(P＜0.05),and the serum sHLA-G level was positively correlated with the CCL20 level(P＜0.05).The areas under receiver operating characteristic(ROC)curves(AUCs)of the serum PGⅠ/PGⅡ,sHLA-G and CCL20 were re-spectively 0.730,0.835 and 0.869 in screening of gastric cancer,and the AUC of the joint detection of the three in-dexes was 0.927,with the sensitivity 93.75％,the specificity 75.49％.CONCLUSION PGⅠ/PGⅡ,sHLA-G and CCL20 may involve in the process of transforming from precancerous lesion with Hp infection to gastric cancer.Serum PGⅠ/PGⅡ,sHLA-G and CCL20 can be used for diagnosis of gastric cancer.
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