Clinical effect of colposcopy combined with loop electrosurgical excision procedure on treatment of human papillomavirus infection-associated cervical precancerous lesions
OBJECTIVE To observe the clinical effect of colposcopy combined with loop electrosurgical excision pro-cedure(LEEP)on treatment of human papillomavirus(HPV)infection-associated cervical precancerous lesions.METHODS Totally 111 patients with HPV infection-associated cervical precancerous lesions who were treated in Beijing Chaoyang Hospital Affiliated to Capital Medical University from Jan 2020 to Dec 2022 were recruited as the research subjects,52 of whom underwent cold knife conization and were assigned as the control group,and 59 underwent the colposcopy combined with LEEP and were assigned as the study group.The curative effect was e-valuated after the treatment for 6 months.The curative effect,surgical indexes,inflammatory factors,complica-tions,recurrent rate and HPV eradication rate were observed and compared between the two groups.RESULTS The total effective rate was higher in the study group(P＜0.05),the intraoperative blood loss volume was less,and the operation duration was shorter(P＜0.05).The levels of peripheral blood tumor necrosis factor(TNF)-α,interleukin(IL)-4 and IL-17 of the two groups were lower after the treatment than before the treatment(P＜0.05).The levels of inflammatory factors of the colposcopy combined LEEP group were significantly lower than those of the control group(P＜0.05).There was no significant difference in the total complications between the two groups.There was no significant difference in the recurrent rate between the two groups.The HPV eradica-tion rate of the study group was higher than that of the control group(P＜0.05).CONCLUSION The colposcopy combined with LEEP can boost the curative effect on the patients with HPV infection-associated cervical precancer-ous lesions,promote the recovery,and raise the HPV eradication rate.It is safe and reliable.
ColposcopyLoop electrosurgical excision procedureHuman papillomavirusCervical precancerous lesionRisk of recurrence
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