首页|剖宫产后产褥期感染病原菌及血清PCT、TAC、NLR水平变化的临床意义

剖宫产后产褥期感染病原菌及血清PCT、TAC、NLR水平变化的临床意义

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目的 探讨剖宫产后产褥期感染病原菌及血清降钙素原(PCT)、总抗氧化能力(TAC)、中性粒细胞与淋巴细胞比值(NLR)水平变化的临床意义.方法 选取2018年1月-2023年6月聊城市第二人民医院产科53例剖宫产后产褥期感染产妇为产褥期感染组,随机选取同期53例剖宫产后无产褥期感染产妇为对照组.分析剖宫产后产褥期感染的病原菌特点;比较产褥期感染组与对照组一般资料和血清PCT、TAC、NLR水平;受试者工作特征(ROC)曲线分析血清PCT、TAC、NLR水平对感染的预测价值.结果 53例剖宫产后产褥期感染产妇检出病原菌79株,以革兰阴性菌为主,其次为支原体;产褥期感染组血清PCT、NLR高于对照组,TAC低于对照组(P<0.05);产褥期感染组患者中,革兰阳性菌感染者血清PCT、NLR水平最高,TAC水平最低(P<0.05);血清PCT、TAC、NLR联合检测预测感染发生的曲线下面积(AUC)为0.891,敏感度为84.91%,均高于各指标单独检测(P<0.05).结论 剖宫产后产褥期感染病原菌以大肠埃希菌、铜绿假单胞菌为主,临床可通过检测剖宫产后血清PCT、NLR和TAC水平预测产褥期感染发生风险.
Pathogens isolated from cesarean section puerpera with postpartum puerperal infections and clinical significance of serum PCT,TAC and NLR
OBJECTIVE To explore the pathogens isolated from the cesarean section puerpera with postpartum pu-erperal infections,observe the changes of serum procalcitonin(PCT),total antioxidant capacity(TAC)and neu-trophils to lymphocytes ratio(NLR),and observe the clinical significance.METHODS A total of 53 cesarean sec-tion puerpera with postpartum puerperal infection who were treated in Liaocheng Second People's Hospital from Jan 2018 to Jun 2023 were assigned as the puerperal infection group,meanwhile,53 cesarean section puerpera who did not have postpartum puerperal infection were chosen as the control group.The pathogens isolated from the pu-erpera with postpartum puerperal infections were analyzed,the baseline data and the levels of serum PCT,TAC and NLR were compared between the puerperal infection group and the control group,and the values of serum PCT,TAC and NLR in prediction of the infection were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS Totally 79 strains of pathogens were isolated from the 53 cesarean section puerpera with postpartum puerperal infection,among which gram-negative bacteria were dominant,followed by Mycoplasma.The levels of serum PCT and NLR of the puerperal infection group were higher than those of the control group,while the TAC of the puerperal infection group was lower than that of the control group(P<0.05).Among the patients of the infection group,the levels of serum PCT and NLR of the patients with gram-positive bacteria infections were the highest during the puerperium,while the TAC was the lowest(P<0.05).The area under curve(AUC)of the joint de-tection of serum PCT,TAC and NLR was 0.891 in prediction of the infections,with the sensitivity 84.91%,higher than those of the single detection(P<0.05).CONCLUSION Escherichia coli and Pseudomonas aeruginosa are dominant a-mong the pathogens isolated from the cesarean section puerpera with postpartum puerperal infection.The clinical detection of serum PCT,NLR and TAC can predict the risk of puerperal infections for the cesarean section.

Cesarean sectionPuerperal infectionSerum procalcitoninTotal antioxidant capacityNeutrophils to lymphocytes ratioPredictive valuePathogen

赵之明、常倩、吕颖欣

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聊城市第二人民医院产科,山东聊城 252600

剖宫产 产褥期感染 血清降钙素原 总抗氧化能力 中性粒细胞与淋巴细胞比值 预测价值 病原菌

山东省卫生厅科研基金资助项目

2022D58

2024

中华医院感染学杂志
中华预防医学会 中国人民解放军总医院

中华医院感染学杂志

CSTPCD北大核心
影响因子:1.885
ISSN:1005-4529
年,卷(期):2024.34(14)
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