Influence of asymptomatic group B Streptococcus infection on vaginal microecology of pregnant women of late pregnancy and on neonatal and maternal outcomes
OBJECTIVE To explore the influence of asymptomatic group B Streptococcus(GBS)infection on the va-ginal microecology of pregnant women of late pregnancy and on the neonatal and maternal outcomes.METHODS A total of 60 pregnant women of late pregnancy who were diagnosed with asymptomatic GBS infection in Taizhou the First People's Hospital from Jan 2021 to Jan 2023 were assigned as the GBS group,and 60 pregnant women of late pregnancy who did not have GBS infection were assigned as the no GBS group.The clinical data,vaginal mi-croecology(vaginal pH value,cleanliness,diversity of flora,dominant bacteria),delivery modes(natural deliver-y,cesarean section),adverse maternal outcomes(premature rupture of membranes,chorioamnionitis,postpar-tum hemorrhage and puerperal infection)and adverse neonatal outcomes(asphyxia,early onset of GBS,low body weight and neonatal pneumonia)were observed and compared between the two groups.RESULTS The proportion of pregnant women with gestational diabetes mellitus of the GBS group was significantly higher than that of the no GBS group(P＜0.05).The proportions of pregnant women with vaginal pH value ranging between 3.8 and 4.5,vaginal cleanliness between Ⅰ and Ⅱ,density of vaginal flora between Ⅲ and Ⅳ,and diversity of vaginal flora be-tween Ⅲ and Ⅳ were significantly lower in the GBS group than in the no GBS group(P＜0.05).There was no sig-nificant difference in the rate of cesarean section between the GBS group and the no GBS group.The incidence rates of premature rupture of membranes and puerperal infection of the GBS group were respectively 21.67％and 16.67％,significantly higher than those of the no GBS group(P＜0.05).The incidence of neonatal pneumonia of the GBS group was significantly higher than that of the no GBS group(P＜0.05).There were no significant differ-ences in the incidence rates of chorioamnionitis,postpartum hemorrhage,neonatal asphyxia,early onset of GBS and low birth weight between the two groups.CONCLUSION The GBS infection may result in the imbalance of va-ginal microecology of the pregnant women of late pregnancy and increase the probability of premature rupture of membranes,puerperal infection and neonatal pneumonia.
Group B StreptococcusLate pregnancyVaginal microecologyPregnancy outcomeNeonate
NETL
NSTL
万方数据
