Progress of research on pharmacogenomics for treatment of SARS-CoV-2 infection
As the novel coronavirus(SARS-CoV-2)infection wreaking havoc around the world,many off-label drugs were urgently used to treat coronavirus disease 2019(COVID-19)due to a lack of specific medication.Phar-macogenomics has been widely applied in several fields of medicine such as cardiovascular,tumor,immunity and other fields.Meantime,it also shows potential clinical application value in prevention and control of COVID-19 ep-idemic,precise medication and development of vaccine.The relevant literatures were reviewed and summarized for the pharmacogenomics of COVID-19,the review focuses on the effects of antiviral micromolecule drugs,hormone drugs,immunomodulatory drugs and non-steroidal anti-inflammatory drugs on treatment of COVID-19 and safe-ty,the progress of research on pharmacogenomics for SARS-CoV-2 vaccine and genetic variation closely associated with severity of COVID-19.In addition,it describes the drug interaction,one of the key factors affecting the pre-cise medication for COVID-19,so as to provide guidance for precise diagnosis and treatment of COVID-19.
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