Research on pathogen distribution,toll-like receptor-4 gene expression and risk factors of urinary tract infection in elderly patients with type 2 diabetes mellitus
OBJECTIVE To analyze the distribution of pathogenic bacteria,toll-like receptor-4(TLR4)gene expres-sion and risk factors of urinary tract infection in elderly patients with type 2 diabetes.METHODS A total of 104 elderly patients with type 2 diabetes and urinary tract infection admitted to the People's Hospital of Qinghai Pro-vincial from Sep 2019 to Sep 2022 were included in the study group,and 117 elderly patients with type 2 diabetes without urinary tract infection were included in the control group.Clinical data of the patients were retrospectively collected.The characteristics of pathogenic bacteria in elderly patients with type 2 diabetes urinary tract infection were analyzed,and clinical data and TLR4 mRNA levels of peripheral neutrophils were compared between the two groups.Multivariate logistic regression analysis was used to analyze the influencing factors of urinary tract infec-tion in elderly patients with type 2 diabetes.RESULTS A total of 121 strains of pathogenic bacteria were isolated from 104 elderly patients with type 2 diabetes and urinary tract infection,including 83 strains of gram-negative bacteria,34 strains of gram-positive bacteria and 4 strains of fungi,accounting for 68.60％,28.10％and 3.31％,respectively.Multivariate logistic analysis showed that increasing age,urinary calculi,invasive procedures,higher serum level of glycated hemoglobin(HbA1c)and peripheral neutrophil mRNA level of TLR4 were risk factors for urinary tract infection in the elderly with type 2 diabetes(P＜0.05),while elevated serum level of albumin(ALB)was a protective factor for urinary tract infection in the elderly with type 2 diabetes(P＜0.05).CONCLUSION The main pathogenic bacteria of urinary tract infection in elderly patients with type 2 diabetes were gram-negative bacteria.Many influencing factors for the urinary tract infection by logistic analysis,and clinical in-tervention can be carried out accordingly.
Old age type 2 diabetes mellitusUrinary tract infectionPathogenic bacteriaToll-like receptor 4Risk factor
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