老年2型糖尿病尿路感染病原菌与危险因素及Toll样受体-4基因表达水平
Research on pathogen distribution,toll-like receptor-4 gene expression and risk factors of urinary tract infection in elderly patients with type 2 diabetes mellitus
李金娟 1许海琦 1刘晓莉 1李永桂 1田雨 1杨历新1
作者信息
- 1. 青海省人民医院内分泌科,青海西宁 810000
- 折叠
摘要
目的 分析老年2型糖尿病尿路感染患者病原菌分布、Toll样受体-4(TLR4)基因表达水平及其影响因素.方法 选取2019年9月—2022年9月青海省人民医院收治的老年2型糖尿病尿路感染患者104例纳入研究组,另择老年2型糖尿病无尿路感染患者117例作为对照组,回顾性收集患者临床资料;分析老年2型糖尿病尿路感染患者病原菌特征,比较两组临床资料及外周血中性粒细胞TLR4 mRNA水平,Logistic回归分析老年2型糖尿病尿路感染的影响因素.结果 104例老年2型糖尿病尿路感染患者共分离出病原菌121株,其中革兰阴性菌83株,革兰阳性菌34株,真菌4株,占比分别为68.60％、28.10％、3.31％;Logistic分析结果显示,年龄升高、泌尿系统结石、入侵式操作、血清糖化血红蛋白(HbA1c)水平升高、外周血中性粒细胞TLR4 mRNA水平升高为老年2型糖尿病尿路感染的危险因素(P＜0.05),血清血红蛋白(ALB)水平升高为老年2型糖尿病尿路感染的保护因素(P＜0.05).结论 老年2型糖尿病尿路感染主要病原菌为革兰阴性菌,Logistic分析结果显示危险因素较多,临床可据此进行针对性干预.
Abstract
OBJECTIVE To analyze the distribution of pathogenic bacteria,toll-like receptor-4(TLR4)gene expres-sion and risk factors of urinary tract infection in elderly patients with type 2 diabetes.METHODS A total of 104 elderly patients with type 2 diabetes and urinary tract infection admitted to the People's Hospital of Qinghai Pro-vincial from Sep 2019 to Sep 2022 were included in the study group,and 117 elderly patients with type 2 diabetes without urinary tract infection were included in the control group.Clinical data of the patients were retrospectively collected.The characteristics of pathogenic bacteria in elderly patients with type 2 diabetes urinary tract infection were analyzed,and clinical data and TLR4 mRNA levels of peripheral neutrophils were compared between the two groups.Multivariate logistic regression analysis was used to analyze the influencing factors of urinary tract infec-tion in elderly patients with type 2 diabetes.RESULTS A total of 121 strains of pathogenic bacteria were isolated from 104 elderly patients with type 2 diabetes and urinary tract infection,including 83 strains of gram-negative bacteria,34 strains of gram-positive bacteria and 4 strains of fungi,accounting for 68.60％,28.10％and 3.31％,respectively.Multivariate logistic analysis showed that increasing age,urinary calculi,invasive procedures,higher serum level of glycated hemoglobin(HbA1c)and peripheral neutrophil mRNA level of TLR4 were risk factors for urinary tract infection in the elderly with type 2 diabetes(P＜0.05),while elevated serum level of albumin(ALB)was a protective factor for urinary tract infection in the elderly with type 2 diabetes(P＜0.05).CONCLUSION The main pathogenic bacteria of urinary tract infection in elderly patients with type 2 diabetes were gram-negative bacteria.Many influencing factors for the urinary tract infection by logistic analysis,and clinical in-tervention can be carried out accordingly.
关键词
老年2型糖尿病/尿路感染/病原菌/Toll样受体4/危险因素Key words
Old age type 2 diabetes mellitus/Urinary tract infection/Pathogenic bacteria/Toll-like receptor 4/Risk factor引用本文复制引用
基金项目
青海省卫生健康委指导性计划(2021-wjzdx-20)
出版年
2024
NETL
NSTL
万方数据