Correlation of ORMDL3 gene single nucleotide polymorphism,serum levels of CX3CL1,CD40L and TGF-β1 with prognosis in children with severe Mycoplasma pneumoniae pneumonia induced asthma
OBJECTIVE To investigate the correlation of mucin-like protein-3(ORMDL3)gene single nucleotide polymorphisms(SNP),serum levels of irregular chemokine human driver protein(CX3CL1),CD40 ligand(CD40L)and transforming growth factor-β1(TGF-β1)with prognosis in children with severe Mycoplasma pneu-moniae(MP)infection induced asthma.METHODS A total of 80 children with asthma induced by severe MP in-fection treated in Qingdao Municipal hospital from Jan 2020 to Aug 2022 were recruited as the group A,and 92 children without asthma after severe MP infection were enrolled in the group B.The clinical data,SNP of ORM-DL3 gene and levels of serum CX3CL1,CD40L and TGF-β1 were compared between two groups,and levels of se-rum CX3CL1,CD40L and TGF-β1 between different prognoses were compared.The predictive value of serum CX3CL1,CD40L,TGF-β1 alone and combined detection in the prognosis of children with asthma induced by se-vere MP infection was analyzed by receiver operating characteristic(ROC)curves.RESULTS The TT genotype and T allele frequencies of rs7216389 locus of ORMDL3 gene in the group A were higher than those in the group B(65.00％vs.44.57％;79.38％vs.63.59％).The frequencies of GG genotype and G allele at rs4794820 locus of ORMDL3 gene in the group A were higher than those in the group B(60.00％vs.42.39％;77.50％vs.61.41％,P＜0.05).Compared with the group B,the levels of serum CX3CL1,CD40L and TGF-β1 in the group A were higher(P＜0.05).Compared with the good prognosis group,the levels of serum CX3CL1,CD40L and TGF-β1 in the poor prognosis group were higher(P＜0.05).The area under the curve(AUCs)of serum CX3CL1,CD40L,TGF-β1 individual and combined detection for predicting the prognosis of children with asthma induced by severe MP infection were 0.636,0.697,0.721 and 0.900,respectively,and the AUC of combined de-tection was the highest(P＜0.05).CONCLUSION ORMDL3 gene single nucleotide polymorphism and CX3CL1,CD40L and TGF-β1 levels are closely related to asthma induced by severe MP infection.CX3CL1,CD40L,TGF-β1 have high predictive value for children with severe MP infection induced asthma,and combined detection has the highest predictive value.
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