OBJECTIVE To analyze the distribution and drug resistance of pathogens isolated from blood culture in the hospital,and to provide reference for the diagnosis and treatment of clinical bloodstream infections.METHODS A retrospective analysis was conducted on the positive blood culture results of clinical samples sent to the Joint Lo-gistic Support Force 969th Hospital from Jan 2020 to Dec 2022,and the drug sensitivity test results were interpre-ted according to the corresponding year standards of the American clinical laboratory standards institute(CLSI).RESULTS A total of 1 490 bacterial strains were isolated from blood samples,including 756 gram-positive bacteria(50.74％)and 734 gram-negative bacteria(49.26％).The main gram-positive bacteria were coagulase negative Staphylococcus,Staphylococcus aureus,Enterococcus faecium,and Enterococcus faecalis.Escherichia coli,Klebsiella pneumoniae,Brucella Malta,and Pseudomonas aeruginosa were the most common gram-negative bacteria.There were certain differences in the composition of bacteria in blood culture between the children and the adults.The detection rate of methicillin-resistant S.aureus(MRSA)was lower than that of methicillin-resistant coagulase negative S.aureus(MRCNS)(P＜0.05).Staphylococcus was 100.00％sensitive to tigecycline,vanco-mycin,and linezolid.The drug resistance rates of faecium was 1.92％.The detection rate of E.coli strains produ-cing broad-spectrum bacteria β-lactamase(ESBLs)was significantly higher than that of K.pneumoniae strains producing ESBLs(P＜0.05).The drug-resistant rates of K.pneumoniae to imipenem and meropenem were 11.61％and 12.50％,respectively,and that of P.aeruginosa to most antibiotics were all＜15％.CONCLUSION There are many types of strains isolated from blood culture,which shows the severe situation of drug resistance.It is necessary to strengthen the pathogen monitoring of bloodstream infections and provide a basis for rational drug use in clinical practice.
Blood cultureBloodstream infectionBacteriaDifferent age groupsAntibioticDrug resistance
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