Distribution and drug resistance of 1 490 strains of bacteria isolated from blood samples
OBJECTIVE To analyze the distribution and drug resistance of pathogens isolated from blood culture in the hospital,and to provide reference for the diagnosis and treatment of clinical bloodstream infections.METHODS A retrospective analysis was conducted on the positive blood culture results of clinical samples sent to the Joint Lo-gistic Support Force 969th Hospital from Jan 2020 to Dec 2022,and the drug sensitivity test results were interpre-ted according to the corresponding year standards of the American clinical laboratory standards institute(CLSI).RESULTS A total of 1 490 bacterial strains were isolated from blood samples,including 756 gram-positive bacteria(50.74％)and 734 gram-negative bacteria(49.26％).The main gram-positive bacteria were coagulase negative Staphylococcus,Staphylococcus aureus,Enterococcus faecium,and Enterococcus faecalis.Escherichia coli,Klebsiella pneumoniae,Brucella Malta,and Pseudomonas aeruginosa were the most common gram-negative bacteria.There were certain differences in the composition of bacteria in blood culture between the children and the adults.The detection rate of methicillin-resistant S.aureus(MRSA)was lower than that of methicillin-resistant coagulase negative S.aureus(MRCNS)(P＜0.05).Staphylococcus was 100.00％sensitive to tigecycline,vanco-mycin,and linezolid.The drug resistance rates of faecium was 1.92％.The detection rate of E.coli strains produ-cing broad-spectrum bacteria β-lactamase(ESBLs)was significantly higher than that of K.pneumoniae strains producing ESBLs(P＜0.05).The drug-resistant rates of K.pneumoniae to imipenem and meropenem were 11.61％and 12.50％,respectively,and that of P.aeruginosa to most antibiotics were all＜15％.CONCLUSION There are many types of strains isolated from blood culture,which shows the severe situation of drug resistance.It is necessary to strengthen the pathogen monitoring of bloodstream infections and provide a basis for rational drug use in clinical practice.
Blood cultureBloodstream infectionBacteriaDifferent age groupsAntibioticDrug resistance
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