Effects of respiratory syncytial virus infection on airway inflammatory injury,serum SAA and CRP levels in AECOPD patients
OBJECTIVE To analyze the risk factors of respiratory syncytial virus(RSV)infection in patients with a-cute exacerbation of chronic obstructive pulmonary disease(AECOPD),and to explore the effects of RSV infec-tion on airway inflammatory injury and serum levels of amyloid A(SAA)and C-reactive protein(CRP).METHODS A total of 50 patients with AECOPD infected with RSV and 50 patients with simple AECOPD in the Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou between Jun 2020 and Jun 2023 were enrolled as the infection group and non-infection group,respectively.The counts of neutrophils(Neu),lympho-cytes(Lym),macrophages(Macro)and eosinophils(Eos)in sputum,serum levels of SAA and CRP in the two groups were detected.The relationship between airway inflammatory injury and serum indexes was analyzed.RESULTS The results of multivariate logistic regression analysis showed that smoking,respiratory failure and ag-gravation frequency within one year were risk factors for RSV infection in AECOPD patients(OR=3.337,4.354,4.229,P＜0.05).Compared with the non-infection group,counts of sputum Neu,Lym,Macro and EOS,and se-rum levels of SAA and CRP were higher in the infection group(P＜0.05).Pearson correlation analysis showed that serum SAA and CRP levels were positively correlated with sputum Neu,Lym,Macro and EOS in the infec-tion group(all P＜0.001).CONCLUSION RSV infection may aggravate airway inflammatory injury and signifi-cantly increase levels of serum SAA and CRP in AECOPD patients.
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