Correlation of levels of SII,NLR,RDW and PLR with pulmonary infection and prognosis after cerebral hemorrhage
OBJECTIVE To explore the correlation of systemic immune inflammation index(SII),peripheral blood neutrophil/lymphocyte ratio(NLR),red blood cell distribution width(RDW),and platelet/lymphocyte ratio(PLR)with pulmonary infection after cerebral hemorrhage,and to evaluate the value on prognosis of patients.METHODS A total of 107 patients with pulmonary infection after cerebral hemorrhage in First Hospital of Wuhan were selected as the infection group,and 80 patients without pulmonary infection after cerebral hemorrhage were included in the non-infection group.The etiological characteristics of all patients with pulmonary infection were an-alyzed.The baseline data and levels of SII,NLR,RDW and PLR were compared between the two groups.The pa-tients were followed up for 3 months after treatment and the patients in infection group were sub-divided into the good prognosis group(n=69)and poor prognosis group(n=38)according to the modified Rankin scale(mRS)score.The levels of SII,NLR,RDW and PLR were compared between the good prognosis group and poor progno-sis group.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of SII,NLR,RDW and PLR levels on prognosis in patients with cerebral hemorrhage and pulmonary infection.RESULTS A to-tal of 148 strains were cultured from sputum samples of 107 patients with cerebral hemorrhage and pulmonary in-fection.Gram-positive bacteria,gram-negative bacteria and fungi accounted for 75.68％,19.59％and 4.73％,re-spectively.Multivariate logistic regression analysis showed that NHISS score at admission,disturbance of con-sciousness,SII,NLR,RDW and PLR were risk factors of pulmonary infection in patients with cerebral hemor-rhage(P＜0.05).The SH,NLR,RDW and PLR were higher in the poor prognosis group than those in the good prognosis group(P＜0.05).ROC curve analysis showed that the sensitivity of SII,NLR,RDW and PLR levels in predicting the prognosis of patients with cerebral hemorrhage and pulmonary infection was 92.11％,the specificity was 60.87％,and the area under curve(AUC)was 0.911.The combined detection had higher diagnostic value.CONCLUSION The elevated levels of SII,NLR,RDW and PLR in patients with cerebral hemorrhage are risk fac-tors of pulmonary infection after infarction,which have high diagnostic value on the prognosis of patients.
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