Diagnostic value of serum miR-223,miR-155 and CCL17 levels in Mycoplasma pneumoniae infection in children and their relationship with disease severity
OBJECTIVE To investigate the diagnostic value of serum micro ribonucleic acid(miR)-223,miR-155 and chemokine ligand 17(CCL17)in Mycoplasma pneumoniae(MP)infection in children and their relationship with the severity of the disease.METHODS A total of 71 cases of MP infection in children admitted to People's Hospital of Yueqing from Apr 2020 to Apr 2023(as the research group)and 72 healthy children under physical examination during the same period(as the control group)were recruited.The children in the research group were divided into the mild group(46 cases)and the severe group(25 cases)according to the severity of the disease.The serum levels of miR-223,miR-155 and CCL17 between the research group and the control group were compared,and the serum levels of miR-223,miR-155 and CCL17 between the mild and the severe groups were compared.The correlation between serum miR-223,miR-155 and CCL17 levels and the severity of the disease was analyzed.The diagnostic value of miR-223,miR-155 and CCL17 levels in the MP infection in children was analyzed.RESULTS Serum levels of miR-223,miR-155 and CCL17 in the research group were higher than those in the con-trol group,and those in the severe group were higher than those in the mild group(P＜0.05).Serum levels miR-223,miR-155 and CCL17 were positively correlated with disease severity,and the area under the curve(AUC)of the combined detection of the three indexes for the diagnosis of MP infection in children was larger than that of single detection(P＜0.05),with the sensitivity and specificity of 88.73％and 88.89％,respectively.CONCLUSION After MP infection in children,the serum levels of miR-223,miR-155 and CCL17 increase,which is more obvious in children with severe infecting children with MP and closely related to the severity of the disease.The combined detection of serum miR-223,miR-155 and CCL17 levels have high diagnostic value for MP infection in children.
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