Diagnostic value of pulmonary ultrasound and IRF5 and IL-10 gene polymorphisms in pulmonary infection of premature infants
OBJECTIVE To investigate the predictive value of pulmonary ultrasound,interferon regulatory factor 5(IRF5)and interleukin(IL)-10 gene polymorphisms for pulmonary infection in preterm infants and the distribu-tion of pathogenic bacteria and inflammatory indicators.METHODS A total of 110 premature infants with pulmo-nary infection admitted to our hospital from Dec 2020 to May 2023 were recruited as the research group,and 120 premature infants without infection were selected as the control group.The clinical data,lung ultrasound scores,gene polymorphisms of IRF5 and IL-10 genes were compared.The predictive value of lung ultrasound and gene polymorphisms of IRF5 and IL-10 in premature infant lung infection were evaluated by receiver operating charac-teristic(ROC)curves.The distribution of pathogenic bacteria was analyzed and the inflammatory indicators be-tween the two groups were compared.RESULTS The proportion of premature rupture of membranes in the re-search group was higher than that in the control group,while the score of lung ultrasound was lower than that in the control group(P＜0.05).The frequencies of the TT genotype and T allele of the IRF5 gene in the research group were 57.27％and 71.82％,respectively,which were higher than 36.67％and51.25％in the control group(P＜0.05).The frequencies of AA genotype and A allele of the IL-10 gene in the research group were 55.45％and 74.09％,respectively,which were higher than 35.00％and 60.83％in the control group(P＜0.05).The ar-ea under the curve(AUC)of combined detection of lung ultrasound,IRF5 and IL-10 gene polymorphisms for pre-dicting pulmonary infection in premature infants was 0.886,with the sensitivity and specificity of 74.55％and 89.17％,respectively.In the study group of 110 cases,virus infection accounted for 21.82％,bacterial infection accounted for 78.18％,of which bacterial infection accounted for a relatively high proportion,mainly Escherichia coli and Staphylococcus epidermidis.The serum levels of IL-6 and tumor necrosis factor a(TNF-a),procalcito-nin(PCT)and C-reactive protein(CRP)in the research group were higher than those in the control group,while the level of serum IL-10 was lower in the control group(P＜0.05).CONCLUSION Premature rupture of mem-branes,pulmonary ultrasound scores,and the variation levels of serum IL-6 and TNF-a,PCT,CRP and IL-10 may be related to the occurrence of pulmonary infection in premature infants,The combined detection of lung ul-trasound,IRF5 and IL-10 gene polymorphisms have high predictive value in lung infection of preterm infants,and the infection was mainly caused by bacteria.Therefore,early diagnosis of pulmonary infection in premature infants can be made and targeted antimicrobial treatment can be given.
NETL
NSTL
万方数据
