Drug resistance and homology of carbapenem-resistant Acinetobacter baumannii strains from intensive care unit of a hospital
OBJECTIVE To investigate the distribution of carbapenem-resistant Acinetobacter baumannii(CRAB)strains in clinical specimens and environmental specimens from intensive care unit(ICU)of a hospital and analyze the drug resistance and homology.METHODS The CRAB strains were isolated from the environment and patients who were treated in ICU of the People's Hospital of Inner Mongolia Autonomous Region from Jan 2020 to Dec 2022,the drug resistance of the strains was analyzed,and the pulse field gel electrophoresis(PFGE)typing was carried out for the strains.RESULTS Totally 846 strains of CRAB were isolated,75.30％of which were isolated from sputum specimens.Among the isolated CRAB strains,34.16％were isolated from neurosurgery critical care department,24.35％were isolated from respiratory critical care department,and 18.68％were isolated from comprehensive critical care department.The drug resistance rates of the CRAB strains to sulfonamides,levofloxa-cin and ciprofloxacin were relatively low,ranging between 80％and 90％;the drug resistance rates to other com-mon antibiotics were more than 95％.PFGE clustering analysis of the 34 strains of CRAB showed that totally 7 types from A to J were acquired,which was dominated by C cluster(11 strains,32.35％),followed by E cluster(7 strains,20.59％).CONCLUSION The isolation rates of CRAB strains are high in the clinical specimens from the patients of neurosurgery ICU and critical care medicine ICU.The strains show high drug resistance rates.There is cross transmission among the patients and between the patients and the environment.It is necessary for the hospital to strengthen the disinfection of the environment and surfaces of medical devices and intensify hand hygiene awareness of health care workers so as to prevent the outbreak of nosocomial infection.
Intensive care unitCarbapenem-resistant Acinetobacter baumanniiDrug resistanceHomologyPulse field gel elecrophoresis
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