Efficiency of Aspergillus fumigatus specific immunoglobulin E antibody in diagnosis of pulmonary aspergillosis
OBJECTIVE To explore the efficiency of Aspergillus fumigatus specific immunoglobulin E(Af-sIgE)antibody in diagnosis of pulmonary aspergillosis(PA).METHODS A total of 22 patients with PA who were treated in Zhongda Hospital,Southeast University from Sep 2019 to Mar 2023 were retrospectively collected as the study group,meanwhile,22 patients who had other pulmonary diseases were chosen as the control group.The clinical data were col-lected from the two groups of patients,the levels of laboratory test indexes[serum(plasma)Af-sIgE,mixed specific IgE(mx-sIgE),total IgE(t-IgE),blood routine and C-reactive protein(CRP)]were observed and compared between the two groups of patients,and receiver operating characteristic(ROC)curves were drawn to assess the diagnostic efficiency.RESULTS The concentrations of serum Af-sIgE,mx-sIgE and t-IgE antibodies of the study group were respective-ly 7.54(0.53,14.30)kUA/L,2.66(0.47,5.56)kUA/L and 1035.00(360.25,2592.50)IU/ml,higher than those of the control group(P＜0.05);there were no significant differences in the levels of blood routine indexes and CRP between the two groups of patients.The result of ROC curve analysis showed that the areas under curves(AUCs)of Af-sIgE,mx-sIgE and t-IgE were respectively 0.945,0.930 and 0.882 in diagnosis of PA;the sensitivities of Af-sIgE and mx-sIgE antibodies were respectively 95.45％and 86.36％in diagnosis of PA;the specificities were 86.36％and 86.36％,respectively.CONCLUSION The patients with PA show the rise of levels of Af-sIgE,mx-sIgE and t-IgE,the indexes have high diagnostic efficiencies and may facilitate the early diagnosis of PA.
Aspergillus fumigatus specific immunoglobulin E antibodyAspergillus fumigatusPulmonary as-pergillosisReceiver operating characteristic curveDiagnostic value
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