IL-17和IL-1β基因多态性与AECOPD合并肺部感染的关联
Association of IL-17 and IL-1β gene polymorphisms with pulmonary infection in AECOPD patients
童惠静 1滕旭升 1孔来法 1程江华 1张晓玲2
作者信息
- 1. 金华市中心医院急诊科,浙江金华 321000
- 2. 金华市中心医院重症医学科,浙江金华 321000
- 折叠
摘要
目的 分析白细胞介素(IL)-17、IL-1β基因多态性与慢性阻塞性肺疾病急性加重期(AECOPD)合并肺部感染的关联.方法 选取2018年1月-2023年6月金华市中心医院收治的AECOPD合并肺部感染患者180例为AECOPD合并感染组,另选取同期收治的未合并肺部感染的AECOPD患者180例为AECOPD组,收集患者住院期间临床资料,分析感染患者病原菌分布特征,检测两组患者外周血IL-17和IL-1β表达水平及其基因多态性.结果 AECOPD合并感染组患者共分离出201株病原菌,革兰阴性菌占比最高为50.25％;与AECOPD组比较,AECOPD合并感染组患者血清IL-17、IL-1β水平分别为(21.74±4.72)pg/ml、(18.41±3.30)pg/ml,均升高(P＜0.05);两组患者IL-17A rs2275913、rs3819024基因型(AA/AG/GG)频率比较均有统计学意义(P＜0.05),IL-1β rs1143634基因型(CC/CT/TT)和等位基因(C、T)频率比较均有统计学意义(P＜0.05).结论 IL-17 rs2275913、rs3819024基因型和IL-1β rs1143634基因型与AECOPD合并肺部感染风险密切相关.
Abstract
OBJECTIVE To analyze the association of interleukin(IL)-17 and IL-1β gene polymorphisms with pul-monary infection in the patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).METHODS A total of 180 AECOPD patients complicated with pulmonary infection who were treated in Jinhua Central Hospital from Jan 2018 to Jun 2023 were assigned as the AECOPD-infection group,meanwhile,180 AE-COPD patients who were not complicated with pulmonary infection were chosen as the AECOPD group.The clini-cal data were collected from the enrolled patients during the hospital stay,the distribution of pathogens isolated from the patients was observed,the expression levels of peripheral blood IL-17 and IL-1β were detected,and the gene polymorphisms were analyzed.RESULTS Totally 201 strains of pathogens were isolated from the patients of the AECOPD-infection group.The proportion of the gram-negative bacteria was the highest(50.25％).The levels of serum IL-17 and IL-1β of the AECOPD-infection group were respectively(21.74±4.72)pg/ml and(18.41±3.30)pg/ml,higher than those of the AECOPD group(P＜0.05).There were significant differences in the frequencies of IL-17A rs2275913 and rs3819024 genotypes(AA/AG/GG)between the two groups of patients(P＜0.05);there were significant differences in the frequencies of IL-1β rs1143634 genotypes(CC/CT/TT)and alleles(C,T)between the two groups of patients(P＜0.05).CONCLUSION The IL-17 rs2275913 and rs3819024 geno-types and IL-1β rs1143634 genotypes are closely associated with the pulmonary infection in the AECOPD patients.
关键词
慢性阻塞性肺疾病急性加重期/肺部感染/病原菌/白细胞介素-17/白细胞介素-1β/基因多态性Key words
Acute exacerbation of chronic obstructive pulmonary disease/Pulmonary infection/Pathogen/Inter-leukin-17/Interleukin-1β/Gene polymorphism引用本文复制引用
基金项目
浙江省中医药科技计划项目(2023ZL188)
出版年
2024
NETL
NSTL
万方数据