Association of IL-17 and IL-1β gene polymorphisms with pulmonary infection in AECOPD patients
OBJECTIVE To analyze the association of interleukin(IL)-17 and IL-1β gene polymorphisms with pul-monary infection in the patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).METHODS A total of 180 AECOPD patients complicated with pulmonary infection who were treated in Jinhua Central Hospital from Jan 2018 to Jun 2023 were assigned as the AECOPD-infection group,meanwhile,180 AE-COPD patients who were not complicated with pulmonary infection were chosen as the AECOPD group.The clini-cal data were collected from the enrolled patients during the hospital stay,the distribution of pathogens isolated from the patients was observed,the expression levels of peripheral blood IL-17 and IL-1β were detected,and the gene polymorphisms were analyzed.RESULTS Totally 201 strains of pathogens were isolated from the patients of the AECOPD-infection group.The proportion of the gram-negative bacteria was the highest(50.25％).The levels of serum IL-17 and IL-1β of the AECOPD-infection group were respectively(21.74±4.72)pg/ml and(18.41±3.30)pg/ml,higher than those of the AECOPD group(P＜0.05).There were significant differences in the frequencies of IL-17A rs2275913 and rs3819024 genotypes(AA/AG/GG)between the two groups of patients(P＜0.05);there were significant differences in the frequencies of IL-1β rs1143634 genotypes(CC/CT/TT)and alleles(C,T)between the two groups of patients(P＜0.05).CONCLUSION The IL-17 rs2275913 and rs3819024 geno-types and IL-1β rs1143634 genotypes are closely associated with the pulmonary infection in the AECOPD patients.
Acute exacerbation of chronic obstructive pulmonary diseasePulmonary infectionPathogenInter-leukin-17Interleukin-1βGene polymorphism
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