Effect of Jiedu Qingfei mixture combined with Montelukast sodium on treatment of bronchial asthma patients complicated with Mycoplasma pneumoniae infection
OBJECTIVE To explore the effect of Jiedu Qingfei mixture combined with Montelukast sodium on treat-ment of bronchial asthma patients complicated with Mycoplasma pneumoniae infection and observe the impact on Toll like receptor 4(TLR4)/nuclear factor-κB(NF-κB)signaling pathways.METHODS A total of 94 bronchial asthma patients who were complicated with M.pneumoniae infection and were treated in Shandong First Medical University Affiliated People's Hospital from Jun 2020 to Jun 2023 were enrolled in the study and randomly divided into the study group with 47 cases and the control group with 47 cases.The control group was treated with Monte-lukast sodium on basis of the routine symptomatic therapy,while the study group was given additional Jiedu Qing-fei mixture on basis of the treatment of the control group.The relative expression levels of peripheral blood TLR4 and NF-κB mRNA were detected after the treatment for 4 weeks.The clinical therapeutic effect,relief of related symptoms,inflammatory factors,lung function,score of asthma control test(ACT)and score of asthma quality of life questionnaire(AQLQ)were observed and compared between the two groups of patients.RESULTS The ef-fective rate of treatment was 91.49％in the study group after the treatment for 4 weeks,74.47％in the control group,and there was significant difference between the two groups(x2=4.821,0.028).The time of recovery of body temperature,time of remission of cough,time of relief of shortness of breath/wheezing and time of relief of sore throat were shorter in the study group than in the control group(P＜0.05).The relative expression levels of peripheral blood TLR4,NF-κB mRNA and the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)as well as the percentage of eosinophils(EOS)of the two groups were lower after the treatment than before the treatment(P＜0.05),and the above indexes were reduced more remarkably in the study group than in the control group(P＜0.05).The forced expiratory volume in one second(FEV1),percentage of forced expiratory volume in the first second to the expected value[(FEV1/FVC)％]and peak expiratory flow(PEF)of the two groups of patients were higher after the treatment than before the treatment(P＜0.05),and the above indexes of the study group were increased more remarkably than those of the control group(P＜0.05).The ACT score and AQLQ score of the two groups of patients were higher after the treatment than before the treat-ment(P＜0.05),and the scores of above indexes of the study group were increased more significantly than those of the control group(P＜0.05).There were no significant adverse reactions in the two groups of patients during the treatment period.CONCLUSION Jiedu Qingfei mixture combined with Montelukast sodium can achieve exact effect on treatment of the bronchial asthma patients complicated with M.pneumoniae infection,improve the lung function and effectively control the asthma.The action mechanisms may be associated with the inhibition of activa-tion of TLR4/NF-κB signaling pathways and the regulation of expression levels of inflammatory factors.
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