Distribution of common pathogens isolated from spinal surgery patients with postoperative pulmonary infection and therapeutic effect of cefuroxime
OBJECTIVE To investigate the distribution of common pathogens isolated from the spinal surgery pa-tients with postoperative pulmonary infection and observe the therapeutic effect of cefuroxime.METHODS A total of 80 patients who underwent spinal surgery and had postoperative pulmonary infection in the First Affiliated Hos-pital of Nanyang Medical College from Apr 2018 to Apr 2023 were recruited as the research subjects.The distribu-tion of pathogens was observed,the enrolled patients were randomly divided into the control group and the study group.The conventional therapies such as reducing phlegm,nutritional support and spasmolysis for asthma relief were carried out after the symptoms like cough,expectoration,fever,shortness of breath and chest tight occurred successively.The control group was given intravenous drip of mezlocillin sodium injection on basis of the above therapies,while the study group was given intravenous drip of cefuroxime injection.The therapeutic effects were evaluated and compared between the two groups after the treatment for 7 days.RESULTS Totally 124 strains of pathogens were isolated from the 80 spinal surgery patients with postoperative pulmonary infection,85(68.55％)of which were gram-negative bacteria.The levels of interleukin-6(IL-6),procalcitonin(PCT)and high sensitivity C-reactive protein(hs-CRP)of the study group were lower than those of the control group after the treatment for 7 days(P＜0.05);the lung function indexes forced vital capacity(FVC),peak expiratory flow(PEF)and forced expiratory volume in one second(FEV1)of the study group were higher than those of the control group(P＜0.05);the score of WHOQOL-BREF scale of the study group were higher than that of the control group(P＜0.05);the clinical pulmonary infection score(CPIS)of the study group was lower than that of the control group(P＜0.05).The two groups of patients did not have significant adverse reactions during the treatment.CONCLUSION The gram-negative bacteria are dominant among the pathogens isolated from the spinal surgery pa-tients with postoperative pulmonary infection.It is necessary for the hospital to take targeted antibacterial thera-pies against the pathogens.Cefuroxime can achieve remarkable effect on treatment of the spinal surgery patients with postoperative pulmonary infection,alleviate the pulmonary infection,improve the illness condition and boost the lung function and quality of life.
Spinal fracturePulmonary infectionDistribution of pathogenCefuroximeLung functionQuality of life
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