Influence of HBV infection and viral load on liver function of pregnant women with gestational diabetes mellitus and pregnancy outcomes
OBJECTIVE To observe the influence of hepatitis B virus(HBV)infection and viral load on liver func-tion of the pregnant women with gestational diabetes mellitus(GDM)and maternal and neonatal outcomes.METHODS A total of 106 GDM pregnant women who were complicated with HBV infection and were treated in Lishui Central Hospital from May 2021 to May 2023 were assigned as the HBV infection group and were divided into the high-load HBV-DNA group with 37 cases,the medium-load HBV-DNA group with 34 cases,and the low-load HBV-DNA group with 35 cases.Meanwhile,53 GDM pregnant women who were not complicated with HBV infection were chosen as the no HBV infection group.The peripheral venous blood specimens were collected to de-tect the liver function indexes serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and glucose metabolism indexes serum fasting plasma glucose(FPG),2h postprandial blood glu-cose(2hPG),glycosylated hemoglobin Alc(HbAlc).The gestational complications and adverse neonatal out-comes were statistically analyzed.RESULTS The levels of ALT,AST,TBIL,FPG,2 hPG and HbAlc of the GDM pregnant women were higher in the HBV infection group than in the no HBV infection group(P＜0.05).The levels of ALT,AST and TBIL of the medium-load HBV-DNA group and the high-load HBV-DNA group were higher those of the low-load HBV-DNA group(P＜0.05),and the levels of the above indexes of the high-load HBV-DNA group were higher than those of the medium-load HBV-DNA group(P＜0.05).The levels of FPG and 2 h PG of the medium-load HBV-DNA group and the high-load HBV-DNA group were higher than those of the low-load HBV-DNA group(P＜0.05).The incidence rates of premature rupture of membranes,gestational hypertension,gestational intrahepatic cholestasis,preterm delivery,neonatal asphyxia and low birth weight were higher in the HBV infection group than in the no HBV infection group(P＜0.05);the incidence rates were higher in the high-load HBV-DNA group(P＜0.05).CONCLUSION The GDM pregnant women complicated with HBV infection have the impaired liver function during the pregnancy,and the pregnant women with medium-load and high-load HBV-DNA have more severe damage of liver function and disturbance of glucose metabolism.
Hepatitis B virusViral loadGestational diabetes mellitusLiver functionPregnancy outcome
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