Characteristics of puerpera with genital tract group B Streptococcus infection and pregnancy outcomes
OBJECTIVE To explore the serotypes,drug resistance and virulence genes in group B Streptococcus(GBS)isolates from the puerpera with genital tract infection and analyze the pregnancy outcomes.METHODS A total of 56 puerpera with genital tract GBS infection who received prenatal examinations in Jinan Second Maternal and Child Health Hospital from Nov 2020 to Nov 2022 were assigned as the study group,and 58 puerpera who re-ceived prenatal examinations but did not have genital tract GBS infection were chosen as the control group.The pregnancy outcomes were compared between the two groups,the drug resistance rates of the genital GBS isolates to the commonly used antibiotics were analyzed;the drug resistance genes,serotypes and virulence genes were ob-served.RESULTS The proportions of puerpera with premature delivery,postpartum hemorrhage were respectively(16.07％),(14.29％)higher in the study group than in the control group(P＜0.05);the result of drug suscepti-bility testing for 56 strains of GBS showed that the strains were sensitive to cefixime,ceftriaxone,penicillin and vancomycin and varied in the drug resistance to levofloxacin,erythromycin,tetracycline and clindamycin.ermB and mef A/E were dominant among the drug resistance genes,while the gyrA and ermTR were less common.The type Ⅰ b and type Ⅰ a were the predominant serotypes,followed by the type Ⅲ,type Ⅱ,type Ⅴ,type Ⅵ and the type NT.The strains that carried with hylB and scpB were dominant among the strains carrying with virulence genes.CONCLUSION The GBS infection may result in the adverse pregnancy outcomes of the puerpera.The GBS strains show varying degree of drug resistance to levofloxacin,erythromycin,tetracycline and clindamycin.The ermB and mef A/E are the major drug resistance genes;the serotype Ⅰ b and Ⅰa are the most common.The strains that carry with hylB and scpB are dominant among the strains carrying with virulence genes.
Genital tractGroup B StreptococcusDrug resistanceSerotypeDrug resistance geneVirulence genePregnancy outcome
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