Clinical value of 25(OH)D and PDCD5 in diagnosis of concurrent myocardial injury in children with Mycoplasma pneumoniae pneumonia
OBJECTIVE To explore the value of serum 25-hydroxyvitamin D[25(OH)D]combined with pro-grammed cell death 5(PDCD5)in prediction of concurrent myocardial injury in the children with Mycoplasma pneumoniae pneumonia(MPP).METHODS A total of 94 children with MPP who were treated in Suzhou Munici-pal Hospital Affiliated to Nanjing Medical University from Nov 2021 to Aug 2023 were recruited as the research subjects and were divided into the myocardial injury group with 35 cases and the non-myocardial injury group with 59 cases.Meanwhile,50 healthy children who received physical examination were chosen as the control group.The baseline data were collected from the three groups of subjects.The expression levels of 25(OH)D,PDCD5,myo-cardial enzyme indexes,inflammation indexes and immune function indexes were detected,and the value of 25(OH)D and PDCD5 in diagnosis of the MMP children complicated with myocardial injury was analyzed by means of receiver operating characteristic(ROC)curves.RESULTS There were significant differences in the expression levels of 25(OH)D,PDCD5,myocardial enzyme indexes,inflammation indexes and immune function indexes a-mong three groups(P＜0.05);the 25(OH)D level of the myocardial injury group was the lowest,with the PD-CD5 the highest(P＜0.05);the expression levels of myocardial enzyme indexes aspartate aminotransferase(AST),lactate dehydrogenase(LDH),creatine kinase(CK)and creatine kinase MB(CK-MB)of the myocardial injury group were the highest(P＜0.05);the expression levels of inflammatory indexes interleukin(IL)-6,IL-8 and tumor necrosis factor-α(TNF-α)were the highest(P＜0.05);the expression levels of immune function inde-xes natural killer(NK)cells,cluster of differentiation 4(CD4+)and CD4+/CD8+of the myocardial injury group were the lowest(P＜0.05).ROC curve analysis showed that the area under curve(AUC)of 25(OH)D combined with PDCD5 was 0.953 in assessment of myocardial injury.CONCLUSION The concurrent myocardial injury may lead to the decline of immune function and enhancement of inflammatory response of the children with MPP.25(OH)D and PDCD5 have high value in prediction of concurrent myocardial injury in the children with MPP.
Serum 25-hydroxyvitamin DProgrammed cell death factorMycoplasma pneumoniae pneumoniaMyocardial injuryDiagnostic value
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