鲍氏不动杆菌噬菌体研究进展
Progress of research on Acinetobacter baumannii phages
王靖 1杨永芳 1杨丽芳 1付雪 1王素娟 1杨锦什 1郭毛毛 1李昊雪1
作者信息
- 1. 内蒙古自治区人民医院医院感染监测科,内蒙古呼和浩特 010010
- 折叠
摘要
碳青霉烯类抗菌药物被誉为对抗病原菌的最后一道防线,然而近年来鲍氏不动杆菌(AB)耐药性增长严重,是世界范围内最具挑战性的医院获得性病原体之一.噬菌体作为细菌的天然杀手,在应对其日益增长的多药耐药性威胁具有巨大潜力.本文综述了目前大部分噬菌体对抗AB的研究,按照单噬菌体疗法、噬菌体鸡尾酒疗法、噬菌体衍生酶来对抗病原体等方面进行分类阐述,并探讨治疗效果,为鲍氏不动杆菌噬菌体的临床应用提供更全面的认识和理论支持.
Abstract
Carbapenem antibiotics are known as the last line of defense against pathogenic bacteria,however,the Acinetobacter baumannii shows an increasingly drug resistance in recent years and has become one of most chal-lenging hospital-acquired pathogens worldwide.As natural killers against bacteria,phages have great potential in tackling the growing threat of multidrug resistance.In this review,most of the current studies on bacteriophage a-gainst A.baumannii were summarized in terms of single phage therapy,bacteriophage cocktail therapy,bacterio-phage derived enzymes against pathogens,and the therapeutic effects were discussed.This paper aims to provide a more comprehensive understanding of A.baumannii phages and theoretical support for the clinical application of A.baumannii phages.
关键词
鲍氏不动杆菌/噬菌体/内溶素/裂解酶Key words
Acinetobacter baumannii/Phage/Endolysin/Depolymerase引用本文复制引用
基金项目
内蒙古自治区卫健委公立医院科研联合基金科技项目(2023GLLH0033)
出版年
2024
NETL
NSTL
万方数据