Feasibility of imipenem-cilastatin sodium combined with low dose of hydrocortisone in treatment of patients with septic shock
OBJECTIVE To analyze the feasibility of imipenem-cilastatin sodium combined with low dose of hydro-cortisone in treatment of the patients with septic shock and observe the influence on serum heat-fatty acid binding protein(H-FABP),procalcitonin(PCT)and C-reactive protein(CRP).METHODS A total of 85 patients with septic shock who were treated in Shaoxing Central Hospital from Jul 2020 to Aug 2022 were enrolled in the study and were divided into the control group with 44 cases and the combination group with 41 cases according to thera-peutic regimen.The control group was treated with low dose of hydrocortisone,while the combination group was given imipenem-cilastatin sodium combined with low dose of hydrocortisone.The curative effect and treatment outcomes were observed and compared between the two groups after the treatment for 7 days.The levels of serum H-FABP,CRP,PCT and immune indexes were observed and compared before the treatment and after the treat-ment for 7 days.The adverse reactions were recorded during the treatment.RESULTS The total effective rate of the combination group was 87.80％after the treatment for 7 days,higher than 68.18％of the control group(P＜0.05).The mechanical ventilation duration and length of hospital stay were shorter in the combination group than in the control group(P＜0.05),and the eradication rate of bacteria of the combination group was higher than that of the control group(P＜0.05).The levels of whole blood CD8+,serum H-FABP,CRP and PCT of the two groups of patients were reduced after the treatment for 7 days(P＜0.05),and the levels of the above indexes of the combination group were reduced more remarkably than those of the control group(P＜0.05).The levels of whole blood CD4+,serum immunoglobulin G(IgG)and IgM of the two groups were elevated(P＜0.05),and the levels of the above indexes of the combination group were elevated more remarkably than those of the control group(P＜0.05).The incidence of adverse reactions of the combination group was 24.39％(10/41)during the treatment,the control group 15.91％(7/44),and there was no significant difference.CONCLUSION Imipenem-cilastatin sodium combined with low dose of hydrocortisone is feasible to treat the patients with septic shock,it can a-chieve exact curative effect,promote the treatment outcome,improve the levels of serum H-FABP,CRP and PCT,re-duce the tissue damage and inflammatory response,and boost the immune function,with the safety favorable.
万方数据
维普
