Etiological characteristics of infectious endocarditis and effect of TGF-β transduction pathway on immunomodulatory regulation
OBJECTIVE To analyze the etiological characteristics of infectious endocarditis(IE)and observe the effect of TGF-β transduction pathway on immunomodulatory regulation.METHODS A total of 35 patients with IE who were treated in cardiology department of Changzhou Second People's Hospital Affiliated to Nanjing Medical University from Feb 2022 to Jan 2023 were assigned as the IE group,and 30 healthy peoples who received physical examination were chosen as the control group.The etiological characteristics of the IE group were analyzed.The levels of inflammatory factors,TGF-β transduction-related proteins and CD4+CD25+regulatory T lymphocytes were detected for the two groups.RESULTS Totally 36 strains of pathogens were isolated from the 35 IE patients,11(30.56％)of which were gram-negative bacteria,24(66.67％)were gram-positive bacteria,and 1(2.78％)was fungus.The expression levels of white blood cell(WBC),C-reactive protein(CRP),procalcitonin(PCT),interleukin(IL)-1β and IL-18 of the IE group were higher than those of the control group(P＜0.05);the relative expression levels of TGF-β1,Smad2,Smad3,p-Smad2 and p-Smad3 proteins of the IE group were higher than those of the control group(P＜0.05),while the CD4+CD25+level of the IE group was lower than that of the con-trol group(P＜0.05).CONCLUSION The IE patients show the abnormal high expressions of TGF-β transduction pathway-related proteins,which may be associated with the immunomodulatory regulation and intervene in the levels of inflammatory factors by mediating the activation of T lymphocytes.
万方数据
维普
