首页|胃复春胶囊联合四联疗法治疗Hp感染胃溃疡的临床效果

胃复春胶囊联合四联疗法治疗Hp感染胃溃疡的临床效果

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目的 分析胃复春胶囊联合四联疗法治疗幽门螺杆菌(Hp)感染胃溃疡的效果及对血清Toll样受体4(TLR4)、髓样分化因子-88(MyD88)、核因子-κB(NF-κB)水平的影响。方法 随机数字表法选取160例2022年6月-2023年6月于杭州市第一人民医院桐庐医院进行治疗的Hp感染胃溃疡患者，纳入对照组与试验组，每组80例，对照组予以四联疗法治疗，试验组予以胃复春胶囊联合四联疗法治疗，分析两组治疗前、后血清TLR4、MyD88、NF-κB水平及胃肠分泌功能，比较两组治疗4周后临床疗效及Hp根治效果。结果 治疗4周后，试验组总有效率、Hp 根治率为 90。00％(72/80)、93。75％(75/80)，高于对照组的 77。50％(62/80)、83。75％(67/80)(P＜0。05);与对照组比较，试验组上腹痛、上腹胀及食欲不振缓解时间更短(P＜0。05);治疗4周后，两组TLR4、MyD88、NF-κB、胃泌素(GAS)、胃蛋白酶原Ⅱ(PGⅡ)水平降低，且试验组更低(P＜0。05)，胃蛋白酶原Ⅰ(PGⅠ)、胃动素(MTL)水平升高，且试验组更高(P＜0。05)。结论 胃复春胶囊治疗Hp感染胃溃疡可调节TLR4、MyD88、NF-κB表达，改善胃肠分泌功能，促进临床症状迅速缓解，可提高疗效及Hp根治效果。
Clinical effect of Weifuchun capsule combined with quadruple therapy on treatment of gastric ulcer with Hp infection
OBJECTIVE To observe the effect of Weifuchun capsule combined with quadruple therapy on treatment of gastric ulcer patients with Helicobacter pylori(Hp)infection and analyze the influence on serum Toll-like re-ceptor(TLR4),myeloid differentiation factor-88(MyD88)and nuclear factor-κB(NF-κB).METHODS Totally 160 gastric ulcer patients with Hp infection who were treated in Hangzhou First People's Hospital Tonglu Hospital from Jun 2022 to Jun 2023 were enrolled in the study and were randomly assigned as the control group and the ex-perimental group,with 80 cases in each group.The control group was treated with quadruple therapy,while the experimental group was treated with Weifuchun capsule combined with quadruple therapy.The levels of serum TLR4,MyD88 and NF-κB as well as gastrointestinal secretion function indexes were compared between the two groups before and after the treatment.The clinical curative effect and eradication effect of Hp were observed and compared between the two groups after the treatment for 4 weeks.RESULTS After the treatment for 4 weeks,the total effective rate of the experimental group was 90.00％(72/80),higher than 77.50％(62/80)of the control group;the eradication rate of Hp of the experimental group was 93.75％(75/80),higher than、83.75％(67/80)of the control group(P＜0.05).The time periods of remission of epigastric pain,epigastric distention and inappe-tence were shorter in the experimental group than in the control group(P＜0.05).The levels of TLR4,MyD88,NF-κB,gastrin(GAS)and pepsinogen Ⅱ(PGⅡ)of the two groups were lower after the treatment for 4 weeks than before the treatment,and the levels of the above indexes of the experimental group were lower than those of the control group(P＜0.05).The levels of pepsinogen Ⅰ(PG Ⅰ)and motilin(MTL)of the two groups were high-er after the treatment for 4 weeks than before the treatment,and the levels of the above indexes of the experimen-tal group were higher than those of the control group(P＜0.05).CONCLUSION Weifuchun capsule can regulate the expressions of TLR4,MyD88 and NF-κB of the gastric ulcer patients with Hp infection,improve the gastroin-testinal secretion function,promote the rapid remission of clinical symptoms,and raise the curative effect as well as the eradication effect of Hp.

Weifuchun capsuleQuadruple therapyHelicobacter pyloriGastric ulcerToll-like receptor 4My-eloid differentiation factor-88Nuclear factor-κBGastrointestinal secretion functionClinical effect

胡闻华、吴鑫莲、路嘉程

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杭州市第一人民医院桐庐医院(桐庐县第一人民医院)消化内科,浙江杭州 311500

胃复春胶囊 四联疗法 幽门螺杆菌 胃溃疡 Toll样受体4 髓样分化因子-88 核因子-κB 胃肠分泌功能 临床疗效

2022年浙江省医学会临床科研基金项目

2022ZYC-A28

2024

10.11816/cn.ni.2024-240015

中华医院感染学杂志
中华预防医学会 中国人民解放军总医院

中华医院感染学杂志

CSTPCD北大核心
影响因子：1.885
ISSN：1005-4529
年,卷(期)：2024.34(18)