Clinical characteristics of lower genital tract microbiota in female patients with single,multiple high-risk human papillomavirus infections
OBJECTIVE To explore the clinical characteristics of lower genital tract microbiota in female patients with single,multiple high-risk human papillomavirus(HR-HPV)infections.METHODS Totally 93 patients who were positive for screening of cervical HR-HPV in Wuhan Integrated Traditional Chinese and Western Medicine Hospital from Jan 2022 to Dec 2023 were enrolled in the study and were divided into the single HR-HPV infection group with 72 cases and the multiple HR-HPV infection group with 21 cases according to the status of HR-HPV infection,meanwhile,452 participants who were tested negative for HR-HPV were chosen as the control group.The cervical exfoliated cell samples were collected from all of the subjects.The subtypes of cervical HR-HPV were detected by polymerase chain reaction(PCR)fluorescence probe,the vaginal secretion specimens were collected to detect Bacterial vaginitis(BV),Trichomonas vaginitis(TV),Vulvovaginal candidiasis(VVC),Ureaplasma ure-alyticum(UU)infection and Chlamydia trachomatis(CT)infection.RESULTS The positive rate of white blood cell counts and positive rate of pH value greater than 4.5 were higher in the multiple HR-HPV infection group than in the single HR-HPV infection group(P＜0.05).There were no significant differences in the positive rates of BV,TV,UU and CT between the single HR-HPV infection group and the multiple HR-HPV infection group.There was association between the abnormal diversity of flora,positive white blood cell count,pH value greater than 4.5,positive BV,positive TV,positive UU and positive CT and the multiple HR-HPV infection(P＜0.05).There was association between the abnormal diversity of flora,positive TV,positive UU,positive CT and the sin-gle HR-HPV infection(P＜0.05).CONCLUSION The HR-HPV infection is closely associated with lower genital tract dysbacteriosis and is associated with BV,TV,UU and CT infections.The multiple HR-HPV infection is more likely to lead to the increase of white blood cell counts and change of vaginal faintly acid.
High-risk human papillomavirusLower genital tractMicrobiotaMultiple infectionRisk factors
万方数据
维普
