缺血性脑卒中患者肺部感染病原菌及其血清HIF-1α、HMGB1和TLR4/NF-κB信号通路的预测价值

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中文摘要：目的研究缺血性脑卒中患者肺部感染病原菌及其血清缺氧诱导因子-1α(HIF-1α)、高迁移率族蛋白B1(HMGB1)和Toll样受体4(TLR4)/核因子-κB(NF-κB)信号通路水平.方法选择2020年6月—2023年6月常熟市第二人民医院收治的80例缺血性脑卒中患者,根据肺部感染情况分为感染组(33例)和非感染组(47例),统计缺血性脑卒中患者肺部感染病原菌特点,比较两组血清HIF-1α、HMGB1和TLR4/NF-κB信号通路指标水平,分析血清HIF-1α、HMGB1和TLR4/NF-κB信号通路对缺血性脑卒中患者肺部感染的预测价值.结果 33例缺血性脑卒中肺部感染患者共培养分离病原菌45株,其中革兰阴性菌27株,革兰阳性菌16株,真菌2株,以铜绿假单胞菌、表皮葡萄球菌、肺炎克雷伯菌为主;感染组血清HIF-1α、HMGB1、TLR4和NF-κB分别为(53.81±9.75)ng/ml、(8.69±2.44)ng/ml、3.07±0.87 和 2.14±0.72 高于非感染组(P＜0.05);血清 HIF-1α、HMGB1和TLR4/NF-κB信号通路指标联合预测缺血性脑卒中患者肺部感染的曲线下面积(AUC)为0.898高于单独检测(P＜0.05).结论缺血性脑卒中患者肺部感染主要感染病原菌种类较多,血清HIF-1α、HMGB1和TLR4/NF-κB信号通路指标联合的预测价值较好.

外文标题：Pathogenesis of pulmonary infection in ischemic stroke patients and its predictive value of serum HIF-1α,HMGB1 and TLR4/NF-κB signaling pathway

外文摘要：OBJECTIVE To investigate the pathogenesis of pulmonary infection in ischemic stroke patients and its predictive value of serum hypoxia-inducible factor-1α(HIF-1α),high mobility group protein B1(HMGB1)and Toll-like receptor 4(TLR4)/nuclear factor-κB(NF-κB)signaling pathway.METHODS A total of 80 patients with ischemic stroke admitted to the No.2 People's Hospital of Changshu from Jun.2020 to Jun.2023 were selected and divided into infection group(33 cases)and non-infection group(47 cases)according to the pulmonary infec-tion.The pathogenesis characteristics of pulmonary infection in ischemic stroke patients were statistically ana-lyzed,the levels of serum HIF-1α,HMGB1 and TLR4/NF-κB signaling pathways were compared between the two groups,and the predictive value of serum HIF-1α,HMGB1 and TLR4/NF-κB signaling pathway for pulmo-nary infection in ischemic stroke patients was analyzed.RESULTS A total of 45 strains of pathogenic bacteria were isolated from 33 patients with pulmonary infection after ischemic stroke,including 27 strains of gram-negative bacteria,16 strains of gram-positive bacteria and 2 strains of fungi,mainly Pseudomonas aeruginosa,Staphylo-coccus epidermidis and Klebsiella pneumoniae.The serum levels of HIF-1 α,HMGB1,TLR4,and NF-κB in the infection group were(53.81±9.75)ng/ml,(8.69±2.44)ng/ml,3.07±0.87 and 2.14±0.72,respectively,higher than those in the non-infection group(P＜0.05).The area under the curve(AUC)of combined detection of serum HIF-1α,HMGB1 and TLR4/NF-κB signaling pathway indexes for the prediction of pulmonary infection in ische-mic stroke patients was 0.898,higher than that of single detection(P＜0.05).CONCLUSION Pulmonary infection in ischemic stroke patients had a wide range of major infectious pathogens,and the combined detetion of serum HIF-1α,HMGB1 and TLR4/NF-κB signaling pathway had a better predictive value.

外文关键词：

Ischemic strokePulmonary infectionPathogenHypoxia inducible factor-1αHigh mobility group protein B1Toll-like receptor 4Nuclear factor-κBSignal pathPredicted value

作者：

陈燕、赵宗波、郁晓丹、顾洋、严满云、卓子良、刘晖

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作者单位：

常熟市第二人民医院神经内科,江苏常熟 215500

关键词：

缺血性脑卒中肺部感染病原菌缺氧诱导因子-1α 高迁移率族蛋白B1 Toll样受体4 核因子-κB 信号通路预测价值

基金：

江苏省医药卫生科技计划基金资助项目苏州市第三十二批科技发展计划(医疗卫生科技创新)基金资助项目

项目编号：

2023KY315SKJY2021009

出版年：

2024

DOI：

10.11816/cn.ni.2024-240170

中华医院感染学杂志

中华预防医学会中国人民解放军总医院

中华医院感染学杂志

CSTPCD北大核心

影响因子：1.885

ISSN：1005-4529

年,卷(期)：2024.34(19)