Diagnostic values of CD14 and CD14+CD16+monocyte levels in liver failure patients complicated with infection and pathogens
OBJECTIVE To investigate the clinical features of concomitant infections in patients with liver failure and the relationship between leukocyte differentiation antigen 14(CD14)and CD14+CDi6+monocytes and co-infec-tion.METHODS Totally 224 patients with liver failure admitted to the Second Hospital of Hebei Medical Universi-ty from Jun.2020 to Dec.2022 were selected as the study subjects,of which 178 patients with concomitant infec-tions were assigned as the infected group,and those without infection were assigned as the uninfected group.The infection site and pathogenic bacteria of patients with liver failure and infection were analyzed.The levels of CD14 and CD14+CD16+monocytes in the two groups were compared,and the diagnostic value of CD14 and CDi4+CD16+monocytes for infections was analyzed by receiver operating characteristic(ROC)curve.RESULTS Totally 224 strains of pathogenic bacteria were cultured and isolated from patients with liver failure and infection,including 36 strains of gram positive bacteria,174 strains of gram negative bacteria,and 14 strains of fungi,with Escherichia coli,Klebsiella pneumoniae,and Pseudomonas aeruginosa predominating.The levels of peripheral blood CD14 and CD14+CD16+monocytes in the infected group were(43.45±12.46)mg/L and(11.17±2.26)％ ,respectively,higher than those in the uninfected group(P＜0.05).ROC curve analysis showed that the cutoff values of CD14 and CDi4+CD16+monocytes in peripheral blood were 15.64 mg/L and 9.76％ ,respectively,and the area under the curve(AUC)were 0.864 and 0.849,respectively.CONCLUSION Patients with liver failure were prone to concomi-tant infections,and the pathogenic bacteria were mainly gram-negative,of which the peripheral CD14 and CD14+CD16+monocytes levels of infected patients were highly expressed,which had good diagnostic values for infec-tions.
Liver failureInfectionPathogenWhite blood cell differentiation antigen 14CD14+CD16+Diagno-sis value
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