Pathogenic bacteria in patients with diabetic foot infection and relationship between serum IL-17,IL-12p70,IL-8 and CRP levels and infection progression
OBJECTIVE To analyze the characteristics of pathogenic bacteria in patients with diabetic foot(DF)in-fection and the relationship between serum interleukin(IL)-17,IL-12p70,IL-8 and C-reactive protein(CRP)lev-els and infection progression.METHODS The clinical data of 68 patients with DF infection(infection group)and 68 patients without DF infection(non-infection group)admitted to Fuyang Cancer Hospital of Anhui Province from Jan.2020 to Oct.2023 were retrospectively analyzed,the pathogenic bacteria in infection group were detec-ted,the levels of serum IL-17,IL-12p70,IL-8 and CRP in the two groups were recorded,the correlation between degree of infection and levels of serum IL-17,IL-12p70,IL-8 and CRP in infected patients was evaluated.The in-fection group was treated with standardized comprehensive treatment.The changes of serum IL-17,IL-12p70,IL-8 and CRP levels in infection group during infection period and infection control period were observed.RESULTS A total of 108 strains of pathogenic bacteria were detected in 68 patients with DF infection,of which 53 strains of gram negative accounted for 49.07％ ,48 strains of gram positive accounted for 44.44％ ,and 7 strains of fungi ac-counted for 6.48％ ;The serum levels of IL-17,IL-12p70,IL-8,and CRP in the infection group were(22.60±4.22)pg/ml,(4.08±0.83)pg/ml,(332.11±35.19)pg/ml and(16.02±3.45)mg/L,respectively,higher than those in the non-infection group(P＜0.05).Spearman rank correlation analysis showed that the degree of DF in-fection was positively correlated with serum IL-17,IL-12p70,IL-8,and CRP levels(r=0.513,0.722,0.896,0.763,all P＜0.001);The serum levels of IL-17,IL-12p70,IL-8,and CRP in the infection group during the in-fection control period were(18.97±3.04)pg/ml,(3.05±0.62)pg/ml,(250.45±33.26)pg/ml,and(11.87±2.35)mg/L,respectively,lower than those of the infection period(P＜0.05).CONCLUSIONS Gram-negative bacteria were the most common pathogenic bacteria in patients with DF infection.Serum IL-17,IL-12p70,IL-8 and CRP might be involved in the disease progression and outcomes of DF infection.
NETL
NSTL
万方数据
