IL-6,STAT3 mRNA and Notch1 mRNA in multiple myeloma and their predictive value for infection and prognosis after chemotherapy
OBJECTIVE To investigate the predictive value of interleukin-6(IL-6),transcriptional activator 3(STAT3)and Notch1 for the diagnosis and prognosis of multiple myeloma after chemotherapy.METHODS A total of 84 patients with multiple myeloma who developed infection within two weeks after chemotherapy treatment in the First Affiliated Hospital of Henan University of Science and Technology from Jun.2020 to Jun.2023 were se-lected as the study group,and 84 patients with multiple myeloma who did not develop infection within two weeks after chemotherapy treatment were selected as the control group.Patients in the study group were followed up for at least 6 months,and were divided into good prognosis group and poor prognosis group according to the follow-up results.The levels of IL-6,STAT3 and Notch1 mRNA in peripheral blood of the two groups were compared,and the diagnostic value of IL-6,STAT3 and Notch1 mRNA levels in peripheral blood in multiple myeloma infection after chemotherapy was analyzed by ROC curve.RESULTS The levels of IL-6,STAT3 mRNA and Notch1 mRNA in study group were 41.12±5.71,2.19±0.42 and 8.15±1.25,respectively,which were higher than those in control group(P＜0.05).The area under the curve(AUC)for the combined detection of IL-6,STAT3 mRNA and Notch1 mRNA levels for the development of infections after chemotherapy in multiple myeloma was 0.953,with a sensitivity of 0.905 and a specificity of 0.869,which were higher than those of the indexes individually(P＜0.05).D-S stage,amyloidosis,IL-6,STAT3 and Notch1 mRNA levels in peripheral blood were compared between the two groups,and the differences were statistically significant(P＜0.05).The D-S stage 11(OR=2.398),amyloidosis(OR=6.692),IL-6(OR=1.298),STAT3 mRNA(OR=2.462)and Notch1 mRNA(OR=1.885)were risk factors for poor prognosis in multiple myeloma patients with infection after chemotherapy(P＜0.05).The AUC of the combined detection of IL-6,STAT3 mRNA and Notch1 mRNA levels for the occur-rence of poor prognosis in patients with multiple myeloma infection after chemotherapy were 0.964,with a sensi-tivity of 0.917 and a specificity of 0.896,which were higher than those of the indexes alone(P＜0.05).CONCLUSION Peripheral blood IL-6,STAT3 and Notch1 mRNA were associated with post-chemotherapy infec-tion in multiple myeloma,which might be used as one of the early predictors of post-chemotherapy infection and prognosis in multiple myeloma.
Multiple myelomaChemotherapyInterleukin-6Transcriptional activator 3Notch1InfectionPrognosisRisk factorPredictive value
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