Effectiveness of doxycycline in the treatment of Mycoplasma pneumoniae pneumonia in azithromycin-resistant children
OBJECTIVE To investigate the efficacy of doxycycline in the treatment of Mycoplasma pneumoniae pneumonia(MPP)in azithromycin-resistant children.METHODS The clinical data of 120 children with azithromy-cin-resistant MPP treated in East Branch of Anji County Third People's Hospital between Aug.2021 and Oct.2023 were collected,and the patients were divided into azithromycin group(65 cases)and doxycycline group(55 cases)according whether doxycycline was applied or not.The curative effect,improvement times of clinical symp-toms,lung function[forced vital capacity(FVC),forced expiratory volume in the first second(FEV,),peak ex-piratory flow(PEF)],inflammatory indexes[C-reactive protein(CRP),lactate dehydrogenase(LDH),D-dimer(DD)],liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST)]and adverse reactions in the two groups were compared.RESULTS The curative effect was better in doxycycline group than az-ithromycin group(P＜0.05).The pyretolysis time,relief time of cough and disappearance time of lung rale in doxycyc-line group were(2.15±0.65)d,(4.59±0.71)d and(5.36±0.84)d,shorter than those in azithromycin group(P＜0.05).After treatment,FVC,FEV,and PEF were significantly increased,while CRP,LDH,DD,ALT and AST were decreased in both groups than before treatment,and the improvement of the above indexes was better in doxycycline group than in the azithromycin group(P＜0.05).There was no statistically significant difference in the incidence of ad-verse reactions between the two groups(P=0.467).CONCLUSION Curative effect of doxycycline was significant in children with azithromycin-resistant MPP,which can significantly promote the recovery of lung function and liver function,and reduce inflammatory response,with a favorable safety profile.
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