Effect of montelukast sodium combined with atomized recombinant human interferon α1b on respiratory syncytial virus infection pneumonia
OBJECTIVE To investigate the effects of Montelukast sodium combined with atomized recombinant hu-man interferon α1b on respiratory syncytial virus(RSV)infection pneumonia and microRNA-146a(miR-146a)and miR-155 levels.METHODS A total of 120 children with RSV pneumonia admitted to the Department of Pediatrics of Shanxi Yingkang Life General Hospital from Oct.2020 to Oct.2023 were retrospectively selected as the study subjects,and they were divided into 74 cases in the combined group and 46 cases in the conventional group accord-ing to the treatment methods.The conventional group was treated with montelukast sodium,while the combined group was treated with Montelukast sodium combined with atomized recombinant human interferon α1b.The clini-cal efficacy,pulmonary function indexes,inflammatory factors,helper T cell 1(Th1)/helper T cell 2(Th2),miR-146a and miR-155 levels were compared between the two groups.RESULTS The curative efficacy of the com-bined group was better than that of conventional group(P=0.030).After treatment,the maximum voluntary ventilation volume(MVV),carbon monoxide dispersion per unit alveolar volume(DLCO/VA)and forced expira-tory volume/forced lung capacity in 1 second(FEV1/FVC)in the combined group were(77.60±9.22),(81.55±9.10)and(86.41±6.83),respectively,higher than those in the conventional group(P＜0.05).After treatment,soluble intercellular adhesion molecule 1(sICAM-1),cysteinylleukotrienes(CysLTs)and interleukin-6(IL-6)in the combined group were(175.46±18.22),(32.47±6.87)and(102.45±16.76),respectively,lower than those in the conventional group,while Interferon-y(IFN-γ)was(46.52±7.89),higher than that in the conventional group(P＜0.05).After treatment,Th1,Th1/Th2 in the combined group were(11.58±2.24)and(2.02±0.64),higher than that in the conventional group,while Th2 was(5.79±1.14),lower than that in the conventional group(P＜0.05).After treatment,the expression of miR-146a in the combined group was(1.64±0.43),higher than that in the conventional group,while the expression of miR-155 was(0.74±0.22),lower than that in the conventional group(P＜0.05).CONCLUSION Montelukast sodium combined with recombi-nant human interferon α1b in the treatment of RSV-infected children with pneumonia improved lung function,re-duced the inflammatory response,regulated the Th1/Th2 immune balance,increased the level of miR-146a and decreased the level of miR-155.
Montelukast sodiumRecombinant human interferon α1bRespiratory syncytial virus infection with pneumoniaCurative effectPlumonary functionImmunityMicroRNA-146aMicroRNA-155
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