目的 探讨特应性皮炎患者幽门螺杆菌(Hp)感染情况及血清白细胞介素(IL)-9、IL-37、维生素D(Vit D)水平与病情的关系。方法 于2021年1月-2023年10月从河北医科大学第二医院选择295例成人特应性皮炎患者为研究组，根据Hp感染情况分为Hp阳性组96例和阴性组199例，同时将Hp阳性组患者病情按特应性皮炎评分指数(SCORAD)分为轻、中、重度三组，另选取301名健康体检者为对照组，分析研究组和对照组Hp感染情况，检测IL-9、IL-37、Vit D水平，并利用Spearman秩相关性分析特应性皮炎Hp感染患者血清IL-9、IL-37、Vit D水平与病情的关系。结果 研究组Hp感染率(32。54％)高于对照组(14。95％)(P＜0。05);与对照组比较，研究组血清IL-9、IL-37水平更高(P＜0。05)，血清Vit D水平更低(P＜0。05);与Hp阴性组比较，Hp阳性组血清IL-9、IL-37水平更高(P＜0。05)，血清Vit D水平更低(P＜0。05);Hp阳性患者重度组血清IL-9、IL-37水平高于中、轻度组(P＜0。05)，中度组高于轻度组(P＜0。05);血清Vit D水平低于中、轻度组(P＜0。05)，中度组低于轻度组(P＜0。05);Spearman秩相关性分析结果显示，特应性皮炎Hp感染患者血清IL-9、IL-37与病情呈正相关(r=0。744、0。743，均 P＜0。05)，血清 Vit D 与病情呈负相关(r=-0。807，P＜0。05)。结论 血清 IL-9、IL-37在特应性皮炎Hp感染患者中呈高表达，而Vit D呈低表达，且三者可参与患者病情进展过程。
Association of IL-9,IL-37 and vitamin D with illness condition of atopic dermatitis patients complicted with Helicobacter pylori infection
OBJECTIVE To explore the prevalence of Helicobacter pylori infection in atopic dermatitis and the asso-ciations of serum interleukin(IL)-9,IL-37,and vitamin D(Vit D)with disease progression.METHODS From Jan.2021 to Oct.2023,a total of 295 adults with atopic dermatitis were selected from Second Hospital of Hebei Medical University as the study group,and divided into H.pylori-positive group with 96 cases and H.pylori-negative groups with 199 cases;H.pylori-positive patients were further divided into the mild,moderate,and se-vere groups according to the scoring atopic dermatitis(SCORAD)outcomes;another 301 healthy subjects under-going physical exams were selected as the control group.The prevalence of H.pylori infection,the serum levels of IL-9,IL-37 and Vit D were tested and compared;the associations of serum IL-9,IL-37 and Vit D with severity of the disease were analyzed by Spearman rank correlation analysis.RESULTS The positive rate of H.pylori in-fection in the study group(32.54％)was significantly higher than that in the control(14.95％)(P＜0.05).Compared with the control group,the serum IL-9 and IL-37 levels in the study group were high(P＜0.05),and serum Vit D level was low(P＜0.05).Compared with the H.pylori-negative group,the serum IL-9 and IL-37 levels in the H.pylori-positive group were high(P＜0.05),and serum Vit D level was low(P＜0.05).Among the mild,moderate and severe groups,serum IL-9 and IL-37 levels were the highest in the severe group(P＜0.05),and higher in the moderate group than those in the mild group(P＜0.05);serum Vit D level was lowest in the severe group(P＜0.05),and lower in the moderate group than that in the mild group(P＜0.05).The Spearman rank correlation analysis showed that serum IL-9,IL-37 were positively correlated with the severity atopic dermatitis with H.pylori infection(r=0.744,0.743,P＜0.05,respectively);serum Vit D was on the contrary(r=-0.807,P＜0.05).CONCLUSINS Serum IL-9 and IL-37 express highly in patients of atopic der-matitis with H.pylori infection;however,Vit D shows a contrary change.All three indexes are involved in dis-ease progression in atopic dermatitis with H.pylori infection.
Atopic dermatitisHelicobacter pyloriInfectionConditionInterleukin-9Interleukin-37Vitamin D
万方数据
维普
