Efficacy of piperacillin-tazobactam combined with moxifloxacin in the treatment of cirrhotic ascites complicated with peritoneal infection
OBJECTIVE To explore the therapeutic effect of piperacillin/tazobactam combined with moxifloxacin in the treatment of cirrhotic ascites complicated with abdominal infection,and serum neutrophil apolipoprotein(HNL),Ghrelin,and monocyte to lymphocyte ratio(MLR)levels.METHODS A total of 100 patients with cir-rhosis ascites combined with abdominal infection admitted to Yingtan People's Hospital from Jun.2020 to Jun.2023 were selected and divided into a combination group(n=62)and a control group(n=38)according to treat-ment methods.The control group was treated with moxifloxacin,and the combination group was treated with pip-eracillin and tazobactam on the basis of control group.The effectiveness,liver function indexes[alanine amin-otransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)],immune function indexes[peripheral blood lymphocytes CD3+,CD4+,CD4+/CD8+]and serum HNL,Ghrelin,MLR levels before and after treatment were compared between the two groups.The occurrence of adverse events was recorded.RESULTS The effectiveness of the combination group was better than that of the control group(P=0.031);After treat-ment,the serum liver function indicators in both groups were lower than before treatment,and the ALT,AST,and ALP levels in the combination group were 135.73±30.62,42.07±9.30,and(31.69±8.75)U/L,respec-tively,which were lower than those in the control group(P＜0.05);After treatment,the levels of immune func-tion indicators in both groups were higher than before treatment,and the CD3+,CD4+,CD4+/CD8+in the com-bination group were(53.29±5.78)％,(44.07±3.52)％,and 1.80±0.45,respectively,which were higher than those in the control group(P＜0.05);After treatment,the serum levels of HNL,Ghrelin,and MLR in both groups were lower than before treatment,and the HNL,Ghrelin,and MLR in the combination group were(109.99±30.14)ng/L,(205.80±36.67)ng/L,and 0.30±0.08,respectively,which were lower than those in the control group(P＜0.05).CONCLUSION Piperacillin-tazobactam combined with moxifloxacin had high effec-tiveness in the treatment of patients with cirrhotic ascites complicated with abdominal infection,and effectively improved the liver function,immune function and serum HNL,Ghrelin and MLR levels.
Piperacillin tazobactamMoxifloxacinCirrhotic ascitesPeritoneal infectionNeutrophil apolipopro-teinGhrelinMonocyte to lymphocyte ratio
万方数据
维普
