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妊娠期泌尿生殖道感染对妊娠结局的影响

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目的 探讨妊娠期泌尿生殖道感染对妊娠结局的影响.方法 选取2017年1月-2022年12月台州市第一人民医院收治的360例妊娠晚期女性,分析其泌尿生殖道感染情况和药物敏感试验结果,根据泌尿生殖道感染情况分为感染组113例与未感染组247例,比较两组妊娠结局.结果 360例妊娠期女性中共有113例发生妊娠期泌尿生殖道感染,占31.39%;单一感染者85例,混合感染者28例,且以支原体感染发生比例最高(19.17%),其次为细菌感染(8.89%)、衣原体感染(7.22%).药物敏感率:支原体对米诺环素(98.55%)、多西环素(95.65%)、交沙霉素(91.30%)较敏感;衣原体对红霉素(92.31%)、交沙霉素(92.31%)、多西环素(96.16%)、克拉霉素(92.31%)较敏感;大肠埃希菌对美罗培南、亚胺培南、替考拉宁敏感(100.00%),表皮葡萄球菌对替考拉宁、乙酰唑胺敏感(100.00%).感染组早产、胎膜早破、绒毛膜羊膜炎、新生儿感染发生率分别为18.58%、20.35%、11.50%、11.50%,高于未感染组(P<0.05);感染组产褥感染、胎儿窘迫、新生儿窒息发生率分别为5.31%、7.08%、6.19%,两组比较差异无统计学意义.结论 妊娠晚期女性泌尿生殖道感染以支原体感染为主,支原体对米诺环素、多西环素、交沙霉素较敏感,感染导致孕妇早产、胎膜早破、绒毛膜羊膜炎、新生儿感染风险升高.
Impact of gestational urogenital tract infections on pregnancy outcomes
OBJECTIVE To explore the impact of gestational urogenital tract infections on pregnancy outcomes.METHOD A total of 360 women in late pregnancy who were treated in Taizhou First People's Hospital between Jan.2017 and Dec.2022 were selected to analyze their urogenital tract infections and the results of drug sensitivity test,which were divided into 113 cases in the infection group and 247 cases in the non-infection group according to presence or absence of urogenital tract infection,and pregnancy outcomes in the two groups were compared.RESULTS Out of 360 pregnant women,a total of 113 cases experienced urinary and reproductive tract infections during pregnancy,accounting for 31.39%.There were 85 cases of single infection and 28 cases of mixed infection,with the highest incidence of mycoplasma infection(19.17%),followed by bacterial infection(8.89%)and chlamydia infection(7.22%).The drug sensitivity rates were as follows:Mycoplasma was more sensitive to mi-nocycline(98.55%),doxycycline(95.65%),and clarithromycin(91.30%).Chlamydia was more sensitive to e-rythromycin(92.31%),clarithromycin(92.31%),doxycycline(96.16%),and clarithromycin(92.31%).Escherichia coli was sensitive to meropenem,imipenem,and teicoplanin(100.00%),while Staphylococcus epi-dermidis was sensitive to teicoplanin and acetazolamide(100.00%).The incidence rates of premature birth,pre-mature rupture of membranes,chorioamnionitis,and neonatal infection in the infection group were 18.58%,20.35%,11.50%,and 11.50%,respectively,which were higher than those in the non-infection group(P<0.05);The incidence rates of postpartum infection,fetal distress,and neonatal asphyxia in the infection group were 5.31%,7.08%,and 6.19%,respectively,with no statistically significant difference between the two groups.CONCLUSION Among the women in late pregnancy,urogenital tract infections were dominated by Myco-plasma infections,which were more sensitive to minocycline,doxycycline and clarithromycin,and infection will result an increased risk of premature delivery,premature rupture of membranes,chorioamnionitis and neonatal in-fection.

Gestational periodUrogenital tract infectionDrug sensitivityPregnancy outcomeRisk factor

陈佳佳、王文强

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台州市第一人民医院妇产科,浙江台州 318020

妊娠期 泌尿生殖道感染 药物敏感性 妊娠结局 危险因素

2024

中华医院感染学杂志
中华预防医学会 中国人民解放军总医院

中华医院感染学杂志

CSTPCD北大核心
影响因子:1.885
ISSN:1005-4529
年,卷(期):2024.34(23)