OBJECTIVE To summerize the procedures of investigation,management,and prevention during the suspected outbreak of nosocomial infection of carbapenem-resistant Klebsiella pneumoniae(CRKP)in the neo-natal intensive care unit(NICU)of a three-A hospital,and to provide the basis for prevention and control the nos-ocomial infection.METHODS An epidemiological survey was carried out on neonates in the NICU who were tested positive for CRKP from Apr.to May 2021.Environmental samples were collected,bacterial strains were se-quenced by next-generation sequencing(NGS),and intervention measures were adopted.RESULTS CRKP was de-tected in 5 newborns in the NICU:one was identified as a colonization,the remaining four were diagnosed as CRKP-associated ventilator pneumonia.All hospital infections occurred in Ward A,totally 59 environmental sam-ples were collected,and the unqualified rate was 13.56％,no strain of CRKP was tetected.NGS analysis revealed significant genetic similarity among 4 CRKP strains.Up to Dec.2023,no more clusters or suspected outbreaks of nosocomial infections were reported in the NICU after a series of comprehensive disposals and preventive meas-ures.CONCLUSION Enhancing the awareness of infection prevention and control of medical staff when performing inva-sive operations,improving hand hygiene compliance,rigorously enforcing isolation protocols,and promptly implementing targeted interventions can play significant roles in decreasing the risks of nosocomial infection outbreaks in the NICU.
关键词
新生儿重症监护病房/医院感染/多重耐药菌/二代测序/医院感染暴发/碳青霉烯类耐药肺炎克雷伯菌
Key words
Neonatal intensive care unit/Nosocomial infection/Multi-drug resistant bacteria/Next-generation se-quencing/Outbreak of nosocomial infection/Carbapenem-resistant Klebsiella pneumoniae
维普
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