Investigation on a suspected outbreak of hospital-associated infection of CRKP in the neonatal intensive care unit of a three-A hospital
OBJECTIVE To summerize the procedures of investigation,management,and prevention during the suspected outbreak of nosocomial infection of carbapenem-resistant Klebsiella pneumoniae(CRKP)in the neo-natal intensive care unit(NICU)of a three-A hospital,and to provide the basis for prevention and control the nos-ocomial infection.METHODS An epidemiological survey was carried out on neonates in the NICU who were tested positive for CRKP from Apr.to May 2021.Environmental samples were collected,bacterial strains were se-quenced by next-generation sequencing(NGS),and intervention measures were adopted.RESULTS CRKP was de-tected in 5 newborns in the NICU:one was identified as a colonization,the remaining four were diagnosed as CRKP-associated ventilator pneumonia.All hospital infections occurred in Ward A,totally 59 environmental sam-ples were collected,and the unqualified rate was 13.56％,no strain of CRKP was tetected.NGS analysis revealed significant genetic similarity among 4 CRKP strains.Up to Dec.2023,no more clusters or suspected outbreaks of nosocomial infections were reported in the NICU after a series of comprehensive disposals and preventive meas-ures.CONCLUSION Enhancing the awareness of infection prevention and control of medical staff when performing inva-sive operations,improving hand hygiene compliance,rigorously enforcing isolation protocols,and promptly implementing targeted interventions can play significant roles in decreasing the risks of nosocomial infection outbreaks in the NICU.
Neonatal intensive care unitNosocomial infectionMulti-drug resistant bacteriaNext-generation se-quencingOutbreak of nosocomial infectionCarbapenem-resistant Klebsiella pneumoniae
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