Value of ultrasound combined with inferior vena cava respiratory variability,CRP,PCT and IL-6 in assessing volume responsiveness in patients with severe pneumonia
OBJECTIVE To investigate the value of ultrasound combined with inferior vena cava respiratory variabil-ity(IVC-RVI),and inflammatory markers including C-reactive protein(CRP),procalcitonin(PCT),and inter-leukin-6(IL-6)in assessing volume responsiveness in patients with severe pneumonia.METHODS A total of 100 patients with severe pneumonia admitted to Xuancheng City Hospital Affiliated to Wannan Medical College from Jan.2020 to Dec.2023 were selected as the study subjects,and the patients were divided into volume-responsive and volume-unresponsive groups according to the results of the volume loading test.The IVC-RVI,CRP,PCT,and IL-6 levels were measured and analyzed in the two groups.Multivariate logistic regression was used to summa-rize the risk factors for volume responsiveness in patients with severe pneumonia.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of IVC-RVI,CRP,PCT,and IL-6 in predicting volume re-sponsiveness in patients with severe pneumonia.RESULTS The CRP,PCT,and IL-6 levels in the volume-unre-sponsive group were(43.76±3.11)mg/L,(18.81±6.12)μg/L,and(31.92±7.72)ng/L,respectively,which were higher than those in the volume-responsive group.Conversely,while IVC-RVI was(16.48±3.82)％,lower than that in the volume-responsive group(P＜0.05).IVC-RVI,CRP,PCT,and IL-6 were risk factors for vol-ume responsiveness in patients with severe pneumonia(P＜0.05).The area under the curve of IVC-RVI,CRP,PCT,and IL-6 alone and their combined detection in predicting volume responsiveness in patients with severe pneumonia were 0.634,0.897,0.849,0.813,and 0.927,respectively,and the combined detection was superior to the individual detection(P＜0.05).CONCLUSIONS IVC-RVI and serum levels of CRP,PCT,and IL-6 were closely associated with volume responsiveness in patients with severe pneumonia.The combination of IVC-RVI,CRP,PCT,and IL-6 levels had some clinical value in predicting volume responsiveness in patients with severe pneumonia.
Inferior vena cava respiratory variabilityC-reactive proteinProcalcitoninInterleukin-6Severe pneu-moniaVolume reactivityRisk factorPredictive value
万方数据
维普
