Risk factors for oral Candida infection in type 2 diabetes mellitus and effect on HNP1-3 and HBD-2 expression
OBJECTIVE To analyze the risk factors for oral Candida infection in patients with type 2 diabetes melli-tus(T2DM)and the effect of infection on human neutrophil defensin 1-3(HNP1-3)and human β-defensin 2(HBD-2)expression in peripheral blood and saliva.METHODS A total of 127 patients with T2DM who were diagnosed in the No.903 Hospital of PLA Joint Logistics Support Force from Aug.2020 to Aug.2023 were selected as the sub-jects;whole saliva were collected,and oral Candida culture and identification were performed.Univariate and multivariate Logistic regression were used to analyze the risk factors for infection.HNP1-3 and HBD-2 levels were measured by ELISA.RESULTS Totally 21 of 127 T2MD patients were carrying oral Candida,including 7 with high CFU counts(≥500 CFU/ml)and 14 with low counts(＜500 CFU/ml).Dental calculus and fasting blood glucose above normal range were the risk factors for oral Candida infection in patients with T2MD(P＜0.05).The levels of HNP1-3 and HBD-2 in peripheral blood and saliva of T2MD patients with infection were higher than those of T2MD patients without infection(P＜0.05).Compared with subjects with low CFU counts,those with high counts had high levels of HNP1-3 and HBD-2 in peripheral blood and saliva(P＜0.05).CONCLUSIONS Pa-tients with T2DM are susceptible to oral Candida infection.There may be a positive correlation between the levels of HNP1-3,HBD-2 in peripheral blood and saliva and oral Candida CFU counts.
万方数据
维普
