Expressions and clinical significances of plasma D-D,Skp2 and p-STAT3 in tumor tissues of gastric cancer
OBJECTIVE To investigate the expression and clinical significance of S-phase kinase related protein 2(SKP2),D-dimer(D-D),phosphorylated signal transducer and activator of transcription 3(p-STAT3)in tissues of gastric carcinoma.METHODS The plasma and tissues of gastric cancer and benign diseases were collected from the 200 patients diagnosed as gastric cancer in oncology department and 200 patients with benign gastric diseases in the department of gastroenterology,the Second People's Hospital of Hengshui from Jan.2021 to Dec.2022.The levels of plasma D-D were detected by immunoturbidimetry,the expressions of SKP2 and p-STAT3 by immuno-histochemistry,and the diagnostic values of the indicators were analyzed by receiver operating characteristic(ROC)curve.RESULTS The positive rates of SKP2 and p-STAT3 and plasma D-D level in gastric cancer group were higher than those in benign group(P＜0.05),higher in Helicobacter pylori positive patients than those in negative ones(P＜0.05),higher in patients with tumor diameter ≥5 cm than those with tumor ≤5 cm(P＜0.05),higher in patients with low differentiation than those with high or middle differentiation(P＜0.05),higher in patients with TNM Stage Ⅲ to Ⅳ than those with TNM Stage Ⅰ to Ⅱ(P＜0.05),higher in the patients with cancer cells infiltrating to serosa than those infiltrating only to muscularis(P＜0.05),higher in the patients with lymph node metastasis or distant metastasis than those without lymph node metastasis or distant metastasis(P＜0.05).The area under the curve(AUC)of combined detection of SKP2 and p-STAT3 and plasma D-D level for the diagnosis of gastric cancer and its distant metastasis was larger than that of the indicator alone(P＜0.05).CONCLUSION The expression changes of Skp2 and p-STAT3 in gastric cancer tissues and plasma D-D level are re-lated to pathological features such as H.pylori infection,tumor differentiation,and depth of invasion;therefore,the combination of these indicators has a diagnostic value for gastric cancer and its distant metastasis.
Helicobacter pylori infectionGastric cancerCancer tissuesS-phase kinase-related protein 2D-di-merPhosphorylated signal transducer and activator of transcription 3
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