Pathogenic bacteria of incision infection and levels of sTREM-1,TLR4,PCT in burn patients undergoing stage Ⅰ postoperative skin and soft tissue expansion scar repair
OBJECTIVE To investigate the pathogenic bacteria of incision infection and serum soluble myeloid trig-gering receptor-1(sTREM-1),Toll-like receptor 4(TLR4),and procalcitoninogen(PCT)levels in burn patients undergoing stage Ⅰ postoperative skin and soft-tissue dilatation scar repair and analyze the values of the indexes in prediction of the postoperative incision infection.METHODS Two hundred and eighty burn patients who underwent stage 1 surgery of skin soft tissue expansion scar repair in Cangzhou City Central Hospital from Jan.2019 to Oct.2023 were selected as the study subjects,and the selected patients were divided into infected(35 cases)and unin-fected(245 cases)groups according to their postoperative incision infections.The pathogenic bacteria of postoper-ative incision infections in stage Ⅰ of burn skin soft tissue expansion scar repair surgery were analyzed,the basic conditions and serum sTREM-1,TLR4 and PCT levels were compared between the two groups,and the infected group was included in the positive and the uninfected group was included in the negative,and the value of sTREM-1,TLR4 and PCT in the prediction of postoperative incision infections in burn patients undergoing stage Ⅰ post-operative skin soft tissue expansion scar repair was analyzed using the receiver operating characteristics(ROC)curves.RESULTS A total of 42 strains of pathogenic bacteria were detected in 35 patients with stage Ⅰ wound in-fection after burn skin and soft tissue expansion scar repair surgery,including 29 strains(69.05％)of gram-nega-tive bacteria and 13 strains(30.95％)of gram-positive bacteria,mainly Pseudomonas aeruginosa.The sTREM-1,TLR4,and PCT levels in the infected group were(15.02±4.13)ng/ml,(6.12±1.98)ng/ml,and(12.36±4.09)ng/ml,respectively,which were higher than those in the uninfected group.The surgery time was(133.87±10.25)minutes,which was longer than that in the uninfected group(P＜0.05).The area under the curve(AUC)value of the combined detection of sTREM-1,TLR4,and PCT for the diagnosis of postoperative incision infection in burn patients undergoing stage Ⅰ skin and soft tissue expansion scar repair surgery was 0.945,which was high-er than that of single detection.CONCLUSION The pathogenic bacteria of postoperative incision infection in burn patients with skin and soft tissue expansion scar repair in stage Ⅰ were mainly gram-negative bacteria,with Pseudomonas aeruginosa predominating,and sTREM-1,TLR4,and PCT were highly expressed in infected pa-tients,and the diagnostic value of the combined detection of the three tests was higher.
BurnSkin and soft tissue expansion scar repairIncision infectionPathogenic bacteriaSoluble mye-loid triggering receptor-1Toll-like receptor 4ProcalcitoninogenPredictive value
万方数据
维普
