NF-κB,TLR4,PCT and PLR in patients with urinary sepsis complicated by infection after flexible ureteroscopic lithotripsy and their predictive value
OBJECTIVE To analyze the nuclear transcription factor-KB(NF-κB),toll-like receptor 4(TLR4),pro-calcitonin(PCT),and platelet-lymphocyte ratio(PLR)in patients with urinary sepsis complicated by infection af-ter flexible ureteroscopic lithotripsy and observe the values of the indexes in prediction of postoperative infection complicated with urinary sepsis.METHODS Totally 103 patients with infection complicating urinary sepsis after flexible ureteroscopic lithotripsy in Qingyang People's Hospital from Oct.2021 to Oct.2023 were selected as the sepsis group,and 115 patients without infection after flexible ureteroscopic lithotripsy were selected as the non-sepsis group.Serum NF-κB,TLR4,PCT and PLR levels were compared between the two groups,Pearson corre-lation coefficient was used to analyze the correlation between NF-κB,TLR4,PCT and PLR and the quality of life of patients with infections complicating urinary sepsis after ureteroscopic lithotripsy,and receiver operating char-acteristics(ROC)curves were used to analyze the predictive value of NF-κB,TLR4,PCT and PLR for infection complicating urinary sepsis in patients after ureteroscopic lithotripsy.RESULTS The levels of WBC,PLR and ser-um NF-κB,TLR4 and PCT in the sepsis group were(10.76±3.25)X 109/L,(213.82±39.02)and(77.61±23.61)pg/ml,(78.63±24.02)and(3.16±1.05)pg/ml respectively,higher than that of the non-sepsis group,while the level of PLT in peripheral blood and scores of quality of life were lower than those in the non-sepsis group(P＜0.05).The levels of serum NF-κB,TLR4,PCT and PLR in peripheral blood of patients with infection complicating urinary sepsis after flexible ureteroscopic lithotripsy were negatively correlated with their quality-of-life scores(P＜0.05).The area under the curve(AUC)value of serum NF-κB,TLR4,PCT and peripheral blood PLR combined to predict infection complicating urinary sepsis after ureteroscopic lithotripsy was 0.853,which was higher than that of the test alone(P＜0.05).CONCLUSIONS Infection complicated with after flexible ureteroscop-ic lithotripsy patients with infection complicating urinary sepsis could cause changes in the levels of relevant labo-ratory indicators and decrease the quality-of-life.Serum levels of NF-κB,TLR4,PCT and peripheral blood PLR were closely related to the quality-of-life of patients,and their combination could effectively improve the predictive value of infection complicating urinary sepsis in paitents after flexible ureteroscopic lithotripsy.
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