Effect of doxycycline hydrochloride combined with azithromycin on treatment of intrauterine adhesion patients complicated with mycoplasma infection
OBJECTIVE To explore the efficacy of doxycycline hydrochloride combined with azithromycin in the se-quential treatment of intrauterine adhesions(IUA)patients with mycoplasma infection and observe the influence on vaginal flora,helper T cell 17(Th17)and related inflammatory factors.METHODS A total of 100 IU patients complicated with mycoplasma infection who were treated in Hengshui People's Hospital from Jan.2021 to Jan.2024 were recruited as the research subjects and were randomly divided into the study group and the control group,with 50 cases in each group.The control group was given azithromycin for sequential treatment,while the study group was given additional doxycycline hydrochloride on basis of the treatment of the control group.The clearance rate of mycoplasma,therapeutic effect,vaginal flora,Th17 cells and the levels of related inflammatory factors were compared between the two groups.RESULTS The clearance rate of mycoplasma of the study group was higher than that of the control group(P＜0.05).The effective rate of treatment of the study group was higher than that of the control group(P＜0.05).The proportions of the patients with grade I to Ⅱ vaginal cleanliness,grade Ⅱ to Ⅲ flora density,grade Ⅱ to Ⅲ flora diversity,pH value ranging between 3.8 and 4.5,grade Ⅱ a of Lactobacilli and normal vaginal microecosystem were higher in the study group than in the control group after the treatment for 5 days(P＜0.05).The percentage of Th17 cells and expression levels of retinoic acid-related orphan receptor gamma t(RORγt),interleukin(IL)-6,IL-17 and IL-22 were lower in the study group after the treat-ment for 5 days than in the control group before the treatment(P＜0.05).CONCLUSION The sequential therapy of doxycycline hydrochloride combined with azithromycin may raise the eradication rate of mycoplasma and effec-tive rate of treatment of the IUA patients complicated with mycoplasma infection,maintain the balance of vaginal flora and reduce the levels of Th17 cell and related inflammatory factors.
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维普
