Relationships between high-risk HPV and protein expressions of cyClinD1,Ki-67 and HER-2 in cervical lesions
OBJECTIVE To investigate the relationships between high-risk human papillomavirus(HPV)and the protein expressions of cell cycle protein(cyClinD1),nuclear associated antigen(Ki-67)and human epidermal growth factor receptor 2(HER-2)in cervical lesions.METHODS This retrospective study included 81 patients with cervical lesions diagnosed at Pingxiang Maternal and Child Health Hospital from Jan.2019 to Dec.2023,in-cluding 24 cases of low-grade cervical squamous intraepithelial lesions(LSIL),30 cases of high-grade cervical squamous intraepithelial lesions(HSIL)and 27 cases of cervical cancer.Clinical data and tissue samples were col-lected.HPV genotyping,cyClinD1,Ki-67 and HER-2 proteins were tested and statistically analyzed.RESULTS The positive rates of high-risk HPV in the three types of cervical lesion tissues were as follows:LSIL＜HSIL＜cervical cancer(P＜0.05).The protein expressions of cyClinD1,Ki-67 and HER-2 in HPV infected cervical lesion tissues were significantly higher than those in non-infected ones(P＜0.05).The concordance rate of high-risk HPV with cyClinD1,Ki-67 and HER-2 protein levels in LSIL was 83.33％,79.17％and 46.43％with kappa val-ues 0.673,0.600 and 0.146,respectively.The concordance rate of high risk HPV with cyClinD1,Ki-67 and HER-2 protein levels in HSIL was 86.67％,96.67％,73.33％with kappa values 0.595,0.870,0.375,respectively.The concordance rate of high risk HPV with cyClinD1,Ki-67 and HER-2 protein levels in cervical cancer was 96.30％,96.30％and 85.19％with kappa values 0.780,0.649 and 0.438,respectively.CONCLUSION CyClinD1,Ki-67 and HER-2 proteins in high-risk HPV-positive cervical lesion tissues express higher than those in negative tissues,which has certain diagnostic value for assessing the tumorigenic stage of cervical lesions.
万方数据
维普
