Risk factors and prediction modeling for hand,foot and mouth disease re-infection in children
OBJECTIVE To analyze the risk factors and build the prediction model for the hand,foot and mouth dis-ease(HFMD)re-infection in children.METHODS A total of 1,200 children with HFMD from Jan.2020 to Dec.2023 were selected from Wuhan Jinyintan hospital information system as the study objects,and divided into re-in-fection group with 80 cases and non-re-infection group with 1,120 cases.The demographic and clinical data were collected,including age,sex,residence,education level of primary guardian,season of onset,population classifi-cation,vaccination,severity,pathogen of initial infection,malnutrition,complicationsand parents'knowledge and behavior.The risk factors were analyzed by logistic analysis,and the prediction model was established and evalua-ted.RESULTS The re-infection rate of HFMD in children was 6.67％,and the risk factors were age ≤3 years,male,scattered living,picky eating and malnutrition(P＜0.05).The vaccination and behavior of the primary guardian were protective factors(P＜0.05).Hosmer-Lemeshow test exhibited satisfactory concordance for predic-ting HFMD re-infection(P=0.495).CONCLUSIONS Certain risks for HFMD re-infection in children still exist in this area,among which young age,male,scattered living,picky eating and malnutrition are the major ones.High-risk HFMD re-infection group can be screened early and paid special attention to;and vaccination should be pro-moted so as to provide early prevention and control of the disease.
万方数据
维普
