NLRP3炎性小体在器官移植不良反应发病机制中的研究进展
Review of research progress on the role of NLRP3 inflammasome in the pathogenesis of adverse reactions of organ transplantation
季媛 1魏巴金2
作者信息
- 1. 330000 南昌,江西省肿瘤医院手术室
- 2. 310003 杭州,浙江大学医学院附属第一医院卫健委多器官联合移植研究重点实验室
- 折叠
摘要
器官移植会产生诸多与炎症相关的不良反应.NLRP3是固有免疫系统中调控炎症反应的重要分子,在肝、肾等器官移植术后发生的缺血再灌注损伤、排斥反应以及微生物感染等不良反应中发挥重要功能.本文对NLRP3在器官移植不良反应发病机制中的作用及调控方式等最新研究进展进行综述.
Abstract
Organ transplantation will lead to some adverse events related to inflammation.NLRP3 inflammasome is an important molecule in the innate immune system that regulates inflammatory responses,NLRP3 plays a key role in adverse events such as ischemia-reperfusion injury,rejection,and microbial infection caused by liver,kidney and other organ transplants.Therefore,this article will review the latest research progress on the pathogenesis and signal pathways of NLRP3 regulation involved in transplantation.
关键词
NLRP3炎性小体/固有免疫/不良反应/移植Key words
NLRP3 inflammasome/Innate immunity/Adverse reaction/Transplantation引用本文复制引用
基金项目
江西省卫生健康委科技计划项目(202211007)
出版年
2023
NETL
NSTL
万方数据