Research progress of collagen in cardiac remodeling after myocardial infarction
Myocardial collagen is the primary component of the extracellular matrix in the cardiomyocardium. It is responsible for maintaining the integrity of the heart structure and cardiomyocyte function and plays an important role in the change of cardiac function and cardiac remodeling after myocardial infarction. Myocardial infarction is a common cardiovascular disease, so it is essential to explore the function of collagen components after myocardial infarction. Myocardial collagen is affected by transforming growth factor-β1/Smads signaling pathway, neuroendocrine and a variety of regulatory molecules. Different types of collagen in the heart serve distinct functions to maintain the normal function of the heart. After myocardial infarction, most of the myocardial collagen exhibits increased expression. However, some collagen, specifically type V collagen, can contribute to an increase in scar area due to its decreasing consumption proportion. Therefore, maintaining an appropriate ratio of collagen is the precondition of maintaining normal heart function. The author reviews the functions of myocardial collagen, the alterations in myocardial collagen after myocardial infarction, the mechanisms of regulating changes in myocardial collagen, and the pharmaceutical interventions that can affect myocardial collagen.
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