Research progress on the biological functions and related diseases mediated by the Eph/Ephrin signal transduction pathways
Erythropoietin-producing hepatocyte (Eph) receptor is the largest receptors among the known receptor tyrosine kinase (RTKs) family. The Eph receptor plays an important role in human ontogeny and various disease development. On the one hand, the interaction between the Eph receptor and its membrane binding ligand (Ephrin) mediates a range of physiological and pathological processes spanning from embryonic development to adulthood. On the other hand, the Eph receptor can contribute to infection and immunity by binding to pathogen-related model molecules, mediating the occurrence and development of associated diseases. This article reviews the latest research progress on the biological functions and related diseases mediated by the Eph/Ephrin signal transduction pathways in recent years and summarizes the role of the Eph receptor and Ephrin in the nervous system, angiogenesis, tumor development, infection, and immunity.
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