利培酮联合奥拉西坦治疗血管性痴呆患者疗效及对认知功能的影响研究
Effect of risperidone combined with oxiracetam on cognitive function in patients with vascular dementia
钱群花 1郑敏1
作者信息
- 1. 201418 上海,上海市奉贤区精神卫生中心精神二科
- 折叠
摘要
目的 探究利培酮联合奥拉西坦治疗对血管性痴呆患者的临床影响.方法 选取上海市奉贤区精神卫生中心84例血管性痴呆(VD)患者作为研究对象,按照入院编码奇偶性将84例VD患者随机分为两组.42例观察组给予利培酮联合奥拉西坦治疗,42例对照组给予奥拉西坦治疗.治疗12周后,比较两组临床疗效、认知功能以及精神行为症状.结果 观察组治疗后总有效率显著高于对照组,总有效率(P＜0.05);治疗后,观察组简易精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MOCA)、画钟试验(CDT)评分显著高于对照组相应指标水平(P＜0.05);观察组治疗后的痴呆病理行为评定量表(BEHAVE-AD)、日常生活能力量表(ADL)评分低于对照组(P＜0.05).结论 利培酮联合奥拉西坦治疗VD有助于提高临床疗效,改善患者认知功能、精神行为症状、日常生活能力.
Abstract
Objective To explore the clinical effect of risperidone combined with oxiracetam on vascular dementia patients.Methods Eighty-four patients with vascular dementia(VD)from Fengxian District mental health center were randomly divided into two groups according to the parity of admission codes.The observation group(n=42)was treated with risperidone combined with oxiracetam,while the control group(n=42)was treat-ed with oxiracetam only.After 12 weeks of treatment,the clinical efficacy,cognitive function,and psychiatric and behavioral symptoms were compared between the two groups.Results the total effective rate in the observation group was significantly higher than that in the control group(P＜0.05),the scores of MMSE,MOCA,and CDT in the observation group were significantly higher than those in the control group(P＜0.05).The scores of BE-HAVE-AD and ADL in the observation group were lower than those in the control group(P＜0.05).Conclu-sion risperidone combined with oxiracetam can improve the clinical efficacy,cognitive function,behavioral symp-toms,and activities of daily living.
关键词
痴呆,血管性/利培酮/奥拉西坦Key words
dementia/vascular/risperidone/oxiracetam引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据