摘要
目的 分析妊娠合并亚临床甲状腺功能减退症(简称"亚临床甲减")与早产相关性.方法 采用回顾性研究方法,选取2021年2月至2023年6月晋江市医院收治的孕妇作为研究对象,收集整理研究对象的临床症状、实验室检查结果及影像学检查结果等资料,最终将82例妊娠亚临床甲减患者纳入观察组,未发生妊娠亚临床甲减的健康孕妇118例纳入对照组.比较分析诱发妊娠亚临床甲减的危险因素及该病与早产的相关性.结果 单因素分析显示,观察组吸烟或长期处于吸烟环境、妊娠高血压、胎盘早剥、胎膜早破、BMI异常、有流产史、妊娠期糖尿病、胎儿生长受限、Hb、TSH、TPOAb、TRAb、妊娠结局与对照组相比,差异有统计学意义(P＜0.05).多因素Logistic回归分析显示,妊娠期糖尿病、妊娠高血压、吸烟或长期处于吸烟环境、胎盘早剥、胎膜早破、BMI异常、有流产史、胎儿生长受限、Hb＜110g/L、TSH＞3.0mIU/L、TPOAb＞34IU/ml、TRAb＞1.71 IU/L为导致孕妇发生妊娠亚临床甲减的高危因素(P=0.000).Pearson程序分析显示,早产与Hb呈负相关,早产与TSH、TPOAb、TRAb呈正相关.结论 妊娠亚临床甲减与妊娠结局密切相关,为有效预防这一问题临床需要加强对高血压、糖尿病、TSH等血清学指标的控制,避免影响妊娠结局.
Abstract
Objective To analyze the incidence of subclinical hypothyroidism(abbreviated as hypothyroidism)during pregnancy in pregnant women,and to analyze the correlation between this disease and preterm birth.Methods Using a retrospective research method,pregnant women admitted to Jinjiang Hospital from February 2021 to June 2023 were selected as the study subjects.Clinical symptoms,laboratory examination results,and imaging examination results of the study subjects were collected and organized.Finally,82 patients with gestational hypothyroidism were included in the observation group,and 118 healthy pregnant women without gestational hypothyroidism were included in the control group.We analyze the risk factors for inducing hypothyroidism during pregnancy and the correlation between this disease and preterm birth.Results Univariate analysis showed that there were statistically significant differences between the observation group and the control group in smoking or long-term smoking environment,pregnancy hypertension,placental abruption,premature rupture of membranes,abnormal BMI,history of abortion,gestational diabetes,fetal growth restriction,Hb,TSH,TPOAb,TRAb,and pregnancy outcomes(P＜0.05).Logistic regression analysis showed that diabetes in pregnancy,pregnancy hypertension,smoking or long-term smoking environment,placental abruption,premature rupture of membranes,abnormal BMI,abortion history,fetal growth restriction,Hb＜110g/L,TSH＞3.0mIU/L,TPOAb＞34IU/ml,TRAb＞1.71IU/L were the high-risk factors leading to hypothyroidism in pregnant women(P=0.000).Pearson program analysis shows that preterm birth is negatively correlated with Hb,while preterm birth is positively correlated with TSH,TPOAb,and TRAb.Conclusion Clinical hypothyroidism is closely related to the pregnancy outcome.In order to effectively prevent this problem,we need to strengthen the control of serological indicators such as hypertension,diabetes,TSH,in order to avoid affecting the pregnancy outcome.
基金项目
泉州市高层次人才创新创业项目(第二批)(2023C014YR)
国家科技期刊平台
NSTL
维普
万方数据