摘要
目的 探讨膳食模式、肠道菌群在胆囊息肉样病变(Polypoid Lesion of Gallbladder,PLG)发生发展中的作用,为PLG的积极防治提供基础依据.方法 通过连续便利抽样方式收集2022年1月至2024年1月就诊于锡林郭勒盟中心医院的PLG患者150例及健康对照者150例,分PLG患者150例为病例组,健康对照者150例为对照组.结果 病例组患者的专性厌氧菌中奇异菌、双歧杆菌均少于对照组(P＜0.05),艰难梭菌多于对照组(P＜0.05),兼性厌氧菌中乳酸菌少于对照组(P＜0.05),链球菌、肠球菌、葡萄球菌均多于对照组(P＜0.05),高密度脂蛋白胆固醇(HDL-C)水平低于对照组(P＜0.05),糖化血红蛋白(HbA1c)、空腹血糖(FBG)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、超敏C反应蛋白(hs-CRP)水平均高于对照组(P＜0.05).奇异菌、罗伊氏乳杆菌均与HbA1c呈负相关(P＜0.05),艰难梭菌与HbA1c呈正相关(P＜0.05),双歧杆菌与TG、LDL-C均呈负相关(P＜0.05),葡萄球菌与hs-CRP呈正相关(P＜0.05),发酵乳杆菌与LDL-C呈负相关(P＜0.05).结论 胆囊息肉患者肠道菌群结构变化与代谢标志物和膳食模式的关系密切.
Abstract
Objective To explore the role of dietary patterns and gut microbiota in the occurrence and development of Polypoid Lesion of Gallbladder(PLG),and provide a basic basis for the active prevention and treatment of PLG.Methods 150 PLG patients(case group)and 150 healthy patients(control group)who visited Xilingol League Central Hospital from January 2022 to January 2024 through continuous convenience sampling were collected.Results Compared to the obligate anaerobe of the control group,in the case group,the number of Bifidobacterium was lower(P＜0.05),and the number of Clostridium difficile was higher(P＜0.05).Compared to the facultative anaerobe of the control group,in the case group,the number of lactic acid bacteria in facultative anaerobic bacteria was lower(P＜0.05),but Streptococcus,Enterococcus,and Staphylococcus were higher(P＜0.05).In the case group HDL-C levels were lower than that in the control group(P＜0.05),and HbA1c,FBG,TG,LDL-C,TC,and hs-CRP levels were higher than those in the control group(P＜0.05).We also found that the number of Bifidobacterium were negatively correlated with HbA1c(P＜0.05),the number of Clostridium difficile was positively correlated with HbA1c(P＜0.05),the number of Bifidobacterium was negatively correlated with TG and LDL-C(P＜0.05),the number of Staphylococcus was positively correlated with hs-CRP(P＜0.05),and the number of Lactobacillus fermentum was negatively correlated with LDL-C(P＜0.05).Conclusion The changes in gut microbiota structure in patients with gallbladder polyps are closely related to metabolic markers and dietary patterns.
国家科技期刊平台
NSTL
万方数据