摘要
目的 分析消化性溃疡伴出血患者幽门螺杆菌(Helicobacter Pylori,HP)感染的情况,探索其临床特点和危险因素.方法 回顾性分析2017年1月至2020年6月莆田学院附属医院消化内科256例消化性溃疡伴出血患者的临床资料.分为HP阴性(42例)、HPI型(98例)、HPⅡ型(116例)三组,比较三组患者的临床资料,血清中胃蛋白酶原(Pepsinogen,PG)、血清CD40、DEFA、IL-10、IL-17、TNF-α水平.结果 HPI型、HPⅡ型患者PGⅠ、PGⅡ、CD40水平均显著高于HP阴性患者(P＜0.05),而DEFA水平显著低于HP阴性患者(P＜0.05);HPⅠ型患者PGⅠ、PGⅡ、CD40水平均显著高于HPⅡ型患者(P＜0.05),而DEFA水平显著低于HPⅡ型患者(P＜0.05).HPⅠ型、HPⅡ型患者IL-10、IL-17、TNF-α水平均显著高于HP阴性患者(P＜0.05);HPI型患者IL-10、IL-17、TNF-α水平均显著高于HPⅡ型患者(P＜0.05).结论 PGⅠ、PGⅡ、CD40、IL-10、IL-17、TNF-α可能是消化性溃疡出血的危险因素,DEFA可能是消化性溃疡出血的保护因素.
Abstract
Objective To analyze the HP infection statusof patients with peptic ulcer and bleeding,and to explore its clinical characteristics and risk factors.Methods The clinical data of 256 patients with peptic ulcer and bleeding in the Department of Gastroenterology of the Affiliated Hospital of Putian University from January 2017 to June 2020 were retrospectively analyzed.The patients were divided into the HP-negative group,the HPI group,and the HPⅡ group,and the clinical data of the three groups were compared,and the levels of PG,CD40,DEFA,IL-10,IL-17,and TNF-α in serum were compared.Results The levels of PGⅠ,PGⅡ,and CD40 in the HPI group and the HPⅡ group were significantly higher than those in the HP-negative group(all P＜0.05),while the levels of DEFA in the HPI group and the HPⅡ group were significantly lower than those in HP-negative patients(P＜0.05).The levels of PGⅠ,PGⅡ,and CD40 in the HPⅠ group were significantly higher than those in the HPⅡgroup(P＜0.05),while the levels of DEFA in the HPⅠ group were significantly lower than those in the HPⅡ group(P＜0.05).The levels of IL-10,IL-17,and TNF-α in the HPⅠ group and the HPⅡ group were significantly higher than those in the HP-negative group(all P＜0.05).The levels of IL-10,IL-17,and TNF-α in the HPⅠ group were significantly higher than those in the HPⅡ group(P＜0.05).Conclusion PGⅠ,PGⅡ,CD40,IL-10,IL-17,and TNF-α may be risk factors for peptic ulcer bleeding,and DEFA may be a protective factor for peptic ulcer bleeding.
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